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Descriptor English: Tilorone
Descriptor Spanish: Tilorona
Descriptor tilorona
Entry term(s) amixina
bis-DEAE-fluorenona
Scope note: Antivíricol utilizado como hidrocloruro. Es el primer compuesto sintético reconocido, de bajo peso molecular, que es un inductor activo de interferón por vía oral. Se ha descrito también que tiene acciones antineoplásicas y antiinflamatorias.
Descriptor Portuguese: Tilorona
Descriptor French: Tilorone
Entry term(s): Amiksin
Amixin
Amyxin
Bis DEAE Fluorenone
Bis-DEAE-Fluorenone
Hydrochloride, Tilorone
Tilorone Hydrochloride
Tree number(s): D02.455.426.559.847.389.850
D04.615.389.850
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D013994
Scope note: An antiviral agent used as its hydrochloride. It is the first recognized synthetic, low-molecular-weight compound that is an orally active interferon inducer, and is also reported to have antineoplastic and anti-inflammatory actions.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Anti-Inflammatory Agents
Antineoplastic Agents
Antiviral Agents
Interferon Inducers
Registry Number: O6W7VEW6KS
CAS Type 1 Name: 9H-Fluoren-9-one, 2,7-bis(2-(diethylamino)ethoxy)-
Previous Indexing: Diethylamines (1974)
Fluorenes (1971-1974)
Public MeSH Note: 91; was see under FLUORENES 1975-90; AMYXIN was indexed under TILORONE/analogs & derivatives 1988-91
Online Note: use TILORONE (NM) to search AMYXIN (NM) 1988-91
History Note: 91(75); was see under FLUORENES 1975-90; AMYXIN was AMYXIN (NM) 1988-91
DeCS ID: 14381
Unique ID: D013994
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1991/01/01
Date of Entry: 1974/11/19
Revision Date: 2013/07/08
Tilorone - Preferred
Concept UI M0021536
Scope note An antiviral agent used as its hydrochloride. It is the first recognized synthetic, low-molecular-weight compound that is an orally active interferon inducer, and is also reported to have antineoplastic and anti-inflammatory actions.
Preferred term Tilorone
Entry term(s) Bis DEAE Fluorenone
Bis-DEAE-Fluorenone
Tilorone Hydrochloride - Narrower
Concept UI M0329668
Preferred term Tilorone Hydrochloride
Entry term(s) Amiksin
Amixin
Amyxin
Hydrochloride, Tilorone



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