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Descriptor English: Bicuculline
Descriptor Spanish: Bicuculina
Descriptor bicuculina
Scope note: Alcaloide de la isoquinolina, obtenido de la Dicenta cucullaria y otras plantas, que es un antagonista competitivo de los receptores GABA-A y provoca convulsiones.
Descriptor Portuguese: Bicuculina
Descriptor French: Bicuculline
Entry term(s): 6-(5,6,7,8-Tetrahydro-6-methyl-1,3-dioxolo(4,5-g)isoquinolin-5-yl)furo(3,4-e)1,3-benzodioxol-8(6H)one
Tree number(s): D03.132.098.077
D03.633.100.531.085.077
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D001640
Scope note: An isoquinoline alkaloid obtained from Dicentra cucullaria and other plants. It is a competitive antagonist for GABA-A receptors.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Convulsants
GABA-A Receptor Antagonists
Registry Number: Y37615DVKC
CAS Type 1 Name: Furo(3,4-e)-1,3-benzodioxol-8(6H)-one, 6-(5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo(4,5-g)isoquinolin-5-yl)-, (R-(R*,S*))-
Previous Indexing: Alkaloids (1972-1974)
Dioxoles (1972-1974)
Isoquinolines (1971-1974)
Public MeSH Note: 80; was see under ISOQUINOLINES 1975-79
History Note: 80(75); was see under ISOQUINOLINES 1975-79
DeCS ID: 1665
Unique ID: D001640
NLM Classification: QV 103
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1980/01/01
Date of Entry: 1974/11/11
Revision Date: 2016/05/27
Bicuculline - Preferred
Concept UI M0002466
Scope note An isoquinoline alkaloid obtained from Dicentra cucullaria and other plants. It is a competitive antagonist for GABA-A receptors.
Preferred term Bicuculline
Entry term(s) 6-(5,6,7,8-Tetrahydro-6-methyl-1,3-dioxolo(4,5-g)isoquinolin-5-yl)furo(3,4-e)1,3-benzodioxol-8(6H)one



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