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Descriptor English: Masoprocol
Descriptor Spanish: Masoprocol
Descriptor Portuguese: Masoprocol
Descriptor French: Masoprocol
Entry term(s): (R*,S*)-4,4'-(2,3-Dimethylbutane-1,4-diyl)bispyrocatechol
Acid, meso-Nordihydroguaiaretic
Actinex
Dihydronorguaiaretic Acid
Nordihydroguaiaretic Acid
Nordihydroguaiaretic Acid, (R*,S*)-Isomer
meso Nordihydroguaiaretic Acid
meso-Nordihydroguaiaretic Acid
Tree number(s): D02.455.426.559.389.140.450.582
D02.455.426.559.389.657.166.550
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D009637
Scope note: A potent lipoxygenase inhibitor that interferes with arachidonic acid metabolism. The compound also inhibits formyltetrahydrofolate synthetase, carboxylesterase, and cyclooxygenase to a lesser extent. It also serves as an antioxidant in fats and oils.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Antioxidants
Lipoxygenase Inhibitors
Cyclooxygenase Inhibitors
Registry Number: 7BO8G1BYQU
CAS Type 1 Name: 1,2-Benzenediol, 4,4'-(2,3-dimethyl-1,4-butanediyl)bis-
Previous Indexing: Catechols (1966-1986)
Public MeSH Note: 2014; see NORDIHYDROGUAIARETIC ACID 1991-2013; see CATECHOLS 1987-1990
History Note: 2014(1987)
DeCS ID: 19266
Unique ID: D009637
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1991/01/01
Date of Entry: 1986/04/09
Revision Date: 2013/07/08
Masoprocol - Preferred
Concept UI M0014961
Scope note A potent lipoxygenase inhibitor that interferes with arachidonic acid metabolism. The compound also inhibits formyltetrahydrofolate synthetase, carboxylesterase, and cyclooxygenase to a lesser extent. It also serves as an antioxidant in fats and oils.
Preferred term Masoprocol
Entry term(s) (R*,S*)-4,4'-(2,3-Dimethylbutane-1,4-diyl)bispyrocatechol
Acid, meso-Nordihydroguaiaretic
Dihydronorguaiaretic Acid
Nordihydroguaiaretic Acid
Nordihydroguaiaretic Acid, (R*,S*)-Isomer
meso Nordihydroguaiaretic Acid
meso-Nordihydroguaiaretic Acid
Actinex - Narrower
Concept UI M0352311
Preferred term Actinex



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