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Descriptor English: Nonsuppressible Insulin-Like Activity
Descriptor Spanish: Actividad Similar a la Insulina no Suprimible
Descriptor actividad insulinoide no suprimible
Entry term(s) NSILA
NSILA-P
NSILA-S
Scope note: Proteína de la sangre (NSILA) que remeda la actividad biológica de la insulina en suero, pero no es suprimida por anticuerpos frente a la insulina. Durante la extracción con ácido-etanol de la fracción III de Crohn, el 10 por ciento de la actividad se encuentra en el sobrenadante (NSILA-S) y la actividad restante en el precipitado (NSILA-P). Éste es un gran compuesto molecular, mucho menos estable que la fracción soluble. La NSILA-S es un factor de crecimiento más potente que la insulina y exhibe actividad de sulfatación.
Descriptor Portuguese: Atividade Insulin-Like não Suprimível
Descriptor French: Activité de type insulinique non suppressible
Entry term(s): Activity, Nonsuppressible Insulin-Like
Activity, Nonsuppressible Insulinlike
Insulin-Like Activity, Nonsuppressible
Insulinlike Activity, Nonsuppressible
NSILA
NSILA-P
NSILA-S
Nonsuppressible Insulin Like Activity
Nonsuppressible Insulinlike Activity
Tree number(s): D12.776.124.862.575
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D009632
Scope note: A blood protein (NSILA) which mimics the biological activity of insulin in serum, but is not suppressed by insulin antibodies. During acid-ethanol extraction of Cohn fraction III, 10% of the activity is found in the supernatant (NSILA-S) and the remaining activity in the precipitate (NSILA-P). The latter is a large molecular compound, much less stable than the soluble fraction. NSILA-S is a more potent growth factor than insulin and exhibits sulfation activity.
Annotation: note category; a blood protein mimicking blood insulin
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: Blood Proteins (1966-1976)
Insulin (1966-1976)
Public MeSH Note: 77
History Note: 77
DeCS ID: 22249
Unique ID: D009632
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1977/01/01
Date of Entry: 1976/05/19
Revision Date: 2006/07/05
Nonsuppressible Insulin-Like Activity - Preferred
Concept UI M0014953
Scope note A blood protein (NSILA) which mimics the biological activity of insulin in serum, but is not suppressed by insulin antibodies. During acid-ethanol extraction of Cohn fraction III, 10% of the activity is found in the supernatant (NSILA-S) and the remaining activity in the precipitate (NSILA-P). The latter is a large molecular compound, much less stable than the soluble fraction. NSILA-S is a more potent growth factor than insulin and exhibits sulfation activity.
Preferred term Nonsuppressible Insulin-Like Activity
Entry term(s) Activity, Nonsuppressible Insulin-Like
Activity, Nonsuppressible Insulinlike
Insulin-Like Activity, Nonsuppressible
Insulinlike Activity, Nonsuppressible
NSILA
Nonsuppressible Insulin Like Activity
Nonsuppressible Insulinlike Activity
NSILA-P - Narrower
Concept UI M0014954
Preferred term NSILA-P
NSILA-S - Narrower
Concept UI M0014955
Preferred term NSILA-S



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