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Descriptor English: Secretory Component
Descriptor Spanish: Componente Secretorio
Descriptor componente secretorio
Entry term(s) pieza secretora
Scope note: Porción extracelular del RECEPTOR DE INMUNOGLOBULINAS POLIMÉRICAS que se encuentra solo o formando complejos con IgA o IgM en una variedad de secreciones externas (lágrimas, bilis, calostro). El componente secretorio deriva por desdoblamiento proteolítico del receptor durante la transcitosis. Cuando las inmunoglobulinas IgA e IgM se unen al receptor durante su transcitosis, el componente secretor se une covalentemente a ellas generando INMUNOGLOBULINA A SECRETORA o INMUNOGLOBULINA M SECRETORA.
Descriptor Portuguese: Componente Secretório
Descriptor French: Composant sécrétoire
Entry term(s): Secretory Piece
Tree number(s): D12.776.124.486.485.114.619.026.030.500
D12.776.124.486.485.705.875
D12.776.124.790.651.114.619.026.030.500
D12.776.124.790.651.705.875
D12.776.377.715.548.114.619.026.030.500
D12.776.377.715.548.705.875
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D012635
Scope note: The extracellular moiety of the POLYMERIC IMMUNOGLOBULIN RECEPTOR found alone or complexed with IGA or IGM, in a variety of external secretions (tears, bile, colostrum.) Secretory component is derived by proteolytic cleavage of the receptor during transcytosis. When immunoglobulins IgA and IgM are bound to the receptor, during their transcytosis secretory component becomes covalently attached to them generating SECRETORY IMMUNOGLOBULIN A or secretory IMMUNOGLOBULIN M.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
DE drug effects
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PO poisoning
RE radiation effects
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Pharm Action: Immunologic Factors
Previous Indexing: Colostrum (1973-1975)
IgA (1973-1975)
Immunoglobulin Fragments (1973-1975)
Public MeSH Note: 91; was see under IMMUNOGLOBULIN FRAGMENTS 1976-90
History Note: 91(76); was see under IMMUNOGLOBULIN FRAGMENTS 1976-90
Entry Version: SECRET COMPONENT
DeCS ID: 22287
Unique ID: D012635
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1991/01/01
Date of Entry: 1975/07/25
Revision Date: 2005/06/30
Secretory Component - Preferred
Concept UI M0019591
Scope note The extracellular moiety of the POLYMERIC IMMUNOGLOBULIN RECEPTOR found alone or complexed with IGA or IGM, in a variety of external secretions (tears, bile, colostrum.) Secretory component is derived by proteolytic cleavage of the receptor during transcytosis. When immunoglobulins IgA and IgM are bound to the receptor, during their transcytosis secretory component becomes covalently attached to them generating SECRETORY IMMUNOGLOBULIN A or secretory IMMUNOGLOBULIN M.
Preferred term Secretory Component
Entry term(s) Secretory Piece



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