Descriptor English: | Captopril | ||||
Descriptor Spanish: |
Captopril
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Descriptor Portuguese: | Captopril | ||||
Descriptor French: | Captopril | ||||
Entry term(s): |
(S)-1-(3-Mercapto-2-methyl-1-oxopropyl)-L-proline Capoten Lopirin SQ 14,225 SQ 14,534 SQ 14225 SQ 14534 SQ-14,225 SQ-14,534 SQ-14225 SQ-14534 SQ14,225 SQ14,534 SQ14225 SQ14534 |
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Tree number(s): |
D12.125.072.401.623.270 |
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RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D002216 | ||||
Scope note: | A potent and specific inhibitor of PEPTIDYL-DIPEPTIDASE A. It blocks the conversion of ANGIOTENSIN I to ANGIOTENSIN II, a vasoconstrictor and important regulator of arterial blood pressure. Captopril acts to suppress the RENIN-ANGIOTENSIN SYSTEM and inhibits pressure responses to exogenous angiotensin. |
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Allowable Qualifiers: |
AA analogs & derivatives AD administration & dosage AE adverse effects AG agonists AI antagonists & inhibitors AN analysis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis EC economics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UR urine |
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Pharm Action: |
Angiotensin-Converting Enzyme Inhibitors Inhibidores de la Enzima Convertidora de Angiotensina Inibidores da Enzima Conversora de Angiotensina Inhibiteurs de l'enzyme de conversion de l'angiotensine inhibidores de la enzima convertidora de angiotensina Antihypertensive Agents Antihipertensivos Anti-Hipertensivos Antihypertenseurs antihipertensivos |
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Registry Number: | 9G64RSX1XD | ||||
CAS Type 1 Name: | L-Proline, 1-(3-mercapto-2-methyl-1-oxopropyl)-, (S)- | ||||
Previous Indexing: |
Kininase II/antagonists & inhibitors (1973-1979) Peptide Peptidohydrolases (1966-1967) /antagonists & inhibitors (1968-1972) Proline (1966-1974) /antagonists & inhibitors (1975-1979) |
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Public MeSH Note: | 86; was see under PROLINE 1980-85; SQ 14225 was see CAPTOPRIL 1980-93 |
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Online Note: | use CAPTOPRIL to search SQ 14225 1980-93 |
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History Note: | 86(80); was see under PROLINE 1980-85; SQ 14225 was see CAPTOPRIL 1980-93 |
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DeCS ID: | 23180 | ||||
Unique ID: | D002216 | ||||
Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||
Date Established: | 1986/01/01 | ||||
Date of Entry: | 1979/05/23 | ||||
Revision Date: | 2013/07/08 |
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CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
|
Captopril
- Preferred
Lopirin
- Narrower
SQ-14,534
- Related but not broader or narrower
Capoten
- Narrower
SQ-14,225
- Narrower
Concept UI |
M0003319 |
Scope note | A potent and specific inhibitor of PEPTIDYL-DIPEPTIDASE A. It blocks the conversion of ANGIOTENSIN I to ANGIOTENSIN II, a vasoconstrictor and important regulator of arterial blood pressure. Captopril acts to suppress the RENIN-ANGIOTENSIN SYSTEM and inhibits pressure responses to exogenous angiotensin. |
Preferred term | Captopril |
Entry term(s) |
(S)-1-(3-Mercapto-2-methyl-1-oxopropyl)-L-proline |
Concept UI |
M0338109 |
Preferred term | Lopirin |
Concept UI |
M0003320 |
Preferred term | SQ-14,534 |
Entry term(s) |
SQ 14,534 SQ 14534 SQ-14534 SQ14,534 SQ14534 |
Concept UI |
M0003322 |
Preferred term | Capoten |
Concept UI |
M0338110 |
Preferred term | SQ-14,225 |
Entry term(s) |
SQ 14,225 SQ 14225 SQ-14225 SQ14,225 SQ14225 |
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