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Descriptor English: Chromomycins
Descriptor Spanish: Cromomicinas
Descriptor cromomicinas
Scope note: Complejo de diversos antibióticos glicosídicos estrechamente relacionados derivados de Streptomyces griseus. Su principal componente, la CROMOMICINA A3, se emplea como colorante fluorescente del ADN, al cual se une inhibiendo la síntesis de ARN. También se emplea como agente antineoplásico, especialmente en tumores sólidos.
Descriptor Portuguese: Cromomicinas
Descriptor French: Chromomycine
Entry term(s): Chromomycin
Tree number(s): D09.408.210
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D002865
Scope note: A complex of several closely related glycosidic antibiotics from Streptomyces griseus. The major component, CHROMOMYCIN A3, is used as a fluorescent stain of DNA where it attaches and inhibits RNA synthesis. It is also used as an antineoplastic agent, especially for solid tumors.
Annotation: antineoplastic antibiotics
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Antibiotics, Antineoplastic
Nucleic Acid Synthesis Inhibitors
Previous Indexing: Antibiotics, Antineoplastic (1967-1971)
Public MeSH Note: 73
History Note: 73(72)
DeCS ID: 23195
Unique ID: D002865
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1973/01/01
Date of Entry: 1999/01/01
Revision Date: 2004/07/07
Chromomycins - Preferred
Concept UI M0004396
Scope note A complex of several closely related glycosidic antibiotics from Streptomyces griseus. The major component, CHROMOMYCIN A3, is used as a fluorescent stain of DNA where it attaches and inhibits RNA synthesis. It is also used as an antineoplastic agent, especially for solid tumors.
Preferred term Chromomycins
Chromomycin - Narrower
Concept UI M0004397
Preferred term Chromomycin



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