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Descriptor English: Thiorphan
Descriptor Spanish: Tiorfan
Descriptor Portuguese: Tiorfano
Descriptor French: Thiorphan
Entry term(s): (3-Mercapto-2-benzylpropionyl)glycine
Thiorphan, (R)-Isomer
Thiorphan, (S)-Isomer
Tiorphan
Tree number(s): D02.886.030.893
D12.125.166.893
D12.125.481.700.750
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D015244
Scope note: A potent inhibitor of membrane metalloendopeptidase (ENKEPHALINASE). Thiorphan potentiates morphine-induced ANALGESIA and attenuates naloxone-precipitated withdrawal symptoms.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Protease Inhibitors
Registry Number: B79L7B5X3Z
CAS Type 1 Name: Glycine, N-(2-(mercaptomethyl)-1-oxo-3-phenylpropyl)-, (+-)-
Previous Indexing: Mercaptopropionylglycine/analogs & derivatives (1980-1988)
Public MeSH Note: 89
History Note: 89
DeCS ID: 23847
Unique ID: D015244
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1989/01/01
Date of Entry: 1988/05/16
Revision Date: 2013/07/08
Thiorphan - Preferred
Concept UI M0023434
Scope note A potent inhibitor of membrane metalloendopeptidase (ENKEPHALINASE). Thiorphan potentiates morphine-induced ANALGESIA and attenuates naloxone-precipitated withdrawal symptoms.
Preferred term Thiorphan
Entry term(s) (3-Mercapto-2-benzylpropionyl)glycine
Tiorphan
Thiorphan, (R)-Isomer - Narrower
Concept UI M0329518
Preferred term Thiorphan, (R)-Isomer
Thiorphan, (S)-Isomer - Narrower
Concept UI M0329519
Preferred term Thiorphan, (S)-Isomer



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