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Descriptor English: Thiorphan
Descriptor Spanish: Tiorfan
Descriptor tiorfan
Scope note: Potente inhibidor de la metaloendopeptidasa (ENCEFALINASA) de la membrana. El tiorfán potencia la ANALGESIA inducida por morfina y atenúa los síntomas de la retirada brusca del naloxone.
Descriptor Portuguese: Tiorfano
Descriptor French: Thiorphan
Entry term(s): N-(2-Benzyl-3-mercaptopropanoyl)glycine
N-(2-Benzyl-3-mercaptopropionyl)glycine
Tree number(s): D02.886.030.893
D12.125.166.893
D12.125.481.700.750
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D015244
Scope note: A potent inhibitor of membrane metalloendopeptidase (ENKEPHALINASE). Thiorphan potentiates morphine-induced ANALGESIA and attenuates naloxone-precipitated withdrawal symptoms.
Allowable Qualifiers: AA analogues et dérivés
AD administration et posologie
AE effets indésirables
AG agonistes
AI antagonistes et inhibiteurs
AN analyse
BL sang
CF liquide cérébrospinal
CH composition chimique
CL classification
CS synthèse chimique
EC économie
HI histoire
IM immunologie
IP isolement et purification
ME métabolisme
PD pharmacologie
PK pharmacocinétique
PO intoxication
RE effets des radiations
SD ressources et distribution
ST normes
TO toxicité
TU usage thérapeutique
UR urine
Pharm Action: Protease Inhibitors
Registry Number: B79L7B5X3Z
CAS Type 1 Name: Glycine, N-(2-(mercaptomethyl)-1-oxo-3-phenylpropyl)-, (+-)-
DeCS ID: 23847
Unique ID: D015244
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1989/01/01
Date of Entry: 1988/05/16
Revision Date: 2013/07/08
Thiorphan - Preferred
Concept UI M0023434
Preferred term Thiorphan
Entry term(s) N-(2-Benzyl-3-mercaptopropanoyl)glycine
N-(2-Benzyl-3-mercaptopropionyl)glycine



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