Descriptor English: | Thiorphan |
Descriptor Spanish: | Tiorfan |
Descriptor Portuguese: | Tiorfano |
Descriptor French: | Thiorphan |
Entry term(s): |
(3-Mercapto-2-benzylpropionyl)glycine Thiorphan, (R)-Isomer Thiorphan, (S)-Isomer Tiorphan |
Tree number(s): |
D02.886.030.893 D12.125.166.893 D12.125.481.700.750 |
RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D015244 |
Scope note: | A potent inhibitor of membrane metalloendopeptidase (ENKEPHALINASE). Thiorphan potentiates morphine-induced ANALGESIA and attenuates naloxone-precipitated withdrawal symptoms. |
Allowable Qualifiers: |
AA analogs & derivatives AD administration & dosage AE adverse effects AG agonists AI antagonists & inhibitors AN analysis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis EC economics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UR urine |
Pharm Action: |
Protease Inhibitors |
Registry Number: | B79L7B5X3Z |
CAS Type 1 Name: | Glycine, N-(2-(mercaptomethyl)-1-oxo-3-phenylpropyl)-, (+-)- |
Previous Indexing: |
Mercaptopropionylglycine/analogs & derivatives (1980-1988) |
Public MeSH Note: | 89 |
History Note: | 89 |
DeCS ID: | 23847 |
Unique ID: | D015244 |
Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents |
Date Established: | 1989/01/01 |
Date of Entry: | 1988/05/16 |
Revision Date: | 2013/07/08 |
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CHEMICALS AND DRUGS
Organic Chemicals [D02]Organic Chemicals -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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Thiorphan
- Preferred
Thiorphan, (R)-Isomer
- Narrower
Thiorphan, (S)-Isomer
- Narrower
Concept UI |
M0023434 |
Scope note | A potent inhibitor of membrane metalloendopeptidase (ENKEPHALINASE). Thiorphan potentiates morphine-induced ANALGESIA and attenuates naloxone-precipitated withdrawal symptoms. |
Preferred term | Thiorphan |
Entry term(s) |
(3-Mercapto-2-benzylpropionyl)glycine Tiorphan |
Concept UI |
M0329518 |
Preferred term | Thiorphan, (R)-Isomer |
Concept UI |
M0329519 |
Preferred term | Thiorphan, (S)-Isomer |
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