DeCS

Descriptor English:

Colorectal Neoplasms, Hereditary Nonpolyposis

Descriptor Spanish:

Neoplasias Colorrectales Hereditarias sin Poliposis

Spanish from Spain

Descriptor	neoplasias colorrectales hereditarias sin poliposis
Entry term(s)	cancer colorrectal hereditario sin poliposis cáncer colorrectal hereditario no asociado a poliposis cáncer colorrectal hereditario no polipósico cáncer colorrectal hereditario no polipósico de tipo 1 cáncer colorrectal hereditario sin poliposis de tipo 1 cáncer de colon familiar no polipósico cáncer de colon familiar no polipósico de tipo 1 cáncer de colon familiar sin poliposis de tipo 1 cáncer de colon hereditario no polipósico cáncer de colon hereditario sin poliposis neoplasias colorrectales no polipósicas hereditarias neoplasias colorrectales sin poliposis hereditarias neoplasias colorrectales sin poliposis hereditarias familiares síndrome de Lynch síndrome de Lynch de tipo I
Scope note:	Grupo de enfermedades hereditarias de carácter autosómico dominante en las que el CÁNCER DE COLON se desarrolla a partir de adenomas aislados. A diferencia de la POLIPOSIS COLÓNICA FAMILIAR, en la que existen cientos de pólipos, las neoplasias colorrectales hereditarias no polipósicas aparecen mucho más tarde, en la cuarta o quinta década de la vida. Las NCNPH se han asociado con mutaciones germinales en los genes reparadores de errores de emparejamiento (GREE). Se subdividen en síndrome de Lynch I o cáncer de colon específico, y SÍNDROME DE LYNCH II, que incluye el cáncer extracólico.

Descriptor Portuguese:

Neoplasias Colorretais Hereditárias sem Polipose

Descriptor French:

Tumeurs colorectales héréditaires sans polypose

Entry term(s):

Colon Cancer, Familial Nonpolyposis
Colon Cancer, Familial Nonpolyposis, Type 1
Colorectal Cancer Hereditary Nonpolyposis
Colorectal Cancer, Hereditary Nonpolyposis, Type 1
Familial Nonpolyposis Colon Cancer
Familial Nonpolyposis Colon Cancer Type 1
Hereditary Nonpolyposis Colon Cancer
Hereditary Nonpolyposis Colorectal Cancer
Hereditary Nonpolyposis Colorectal Cancer Type 1
Hereditary Nonpolyposis Colorectal Neoplasms
Lynch Cancer Family Syndrome I
Lynch Syndrome
Lynch Syndrome I
Syndrome, Lynch

Tree number(s):

C04.588.274.476.411.307.190
C04.700.250
C06.301.371.411.307.190
C06.405.249.411.307.190
C06.405.469.158.356.190
C06.405.469.491.307.190
C16.320.700.250
C18.452.284.255

RDF Unique Identifier:

https://id.nlm.nih.gov/mesh/D003123

Scope note:

A group of autosomal-dominant inherited diseases in which COLON CANCER arises in discrete adenomas. Unlike FAMILIAL POLYPOSIS COLI with hundreds of polyps, hereditary nonpolyposis colorectal neoplasms occur much later, in the fourth and fifth decades. HNPCC has been associated with germline mutations in mismatch repair (MMR) genes. It has been subdivided into Lynch syndrome I or site-specific colonic cancer, and LYNCH SYNDROME II which includes extracolonic cancer.

Allowable Qualifiers:

BL blood
BS blood supply
CF cerebrospinal fluid
CH chemistry
CI chemically induced
CL classification
CO complications
DG diagnostic imaging
DH diet therapy
DI diagnosis
DT drug therapy
EC economics
EH ethnology
EM embryology
EN enzymology
EP epidemiology
ET etiology
GE genetics
HI history
IM immunology
ME metabolism
MI microbiology
MO mortality
NU nursing
PA pathology
PC prevention & control
PP physiopathology
PS parasitology
PX psychology
RH rehabilitation
RT radiotherapy
SC secondary
SU surgery
TH therapy
UL ultrastructure
UR urine
VE veterinary
VI virology

Concept UI	M0004834
Scope note	A group of autosomal-dominant inherited diseases in which COLON CANCER arises in discrete adenomas. Unlike FAMILIAL POLYPOSIS COLI with hundreds of polyps, hereditary nonpolyposis colorectal neoplasms occur much later, in the fourth and fifth decades. HNPCC has been associated with germline mutations in mismatch repair (MMR) genes. It has been subdivided into Lynch syndrome I or site-specific colonic cancer, and LYNCH SYNDROME II which includes extracolonic cancer.
Preferred term	Colorectal Neoplasms, Hereditary Nonpolyposis
Entry term(s)	Hereditary Nonpolyposis Colorectal Neoplasms

Concept UI	M0444331
Scope note	HNPCC with no history of associated cancers.
Preferred term	Hereditary Nonpolyposis Colorectal Cancer
Entry term(s)	Colon Cancer, Familial Nonpolyposis Colorectal Cancer Hereditary Nonpolyposis Familial Nonpolyposis Colon Cancer Hereditary Nonpolyposis Colon Cancer

Concept UI	M000655656
Preferred term	Lynch Syndrome
Entry term(s)	Syndrome, Lynch

Concept UI	M000738553
Preferred term	Lynch Syndrome I
Entry term(s)	Colon Cancer, Familial Nonpolyposis, Type 1 Colorectal Cancer, Hereditary Nonpolyposis, Type 1 Familial Nonpolyposis Colon Cancer Type 1 Hereditary Nonpolyposis Colorectal Cancer Type 1 Lynch Cancer Family Syndrome I

We want your feedback on the new DeCS / MeSH website

We invite you to complete a survey that will take no more than 3 minutes.