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Descriptor English: Proguanil
Descriptor Spanish: Proguanil
Descriptor proguanil
Entry term(s) cloroguanida
Scope note: Compuesto de biguanida con escasa actividad antimalárica hasta que es metabolizada en el organismo dando lugar al agente antimalárico efectivo cicloguanil. La utilidad del proguanil es limitada por el rápido desarrollo de resistencia del parásito de la malaria. El clorhidrato se utiliza para la profilaxis ocasional de la malaria falciparum, para inhibir otras formas de malaria y para reducir la transmisión de la infección. (Martindale, The Extra Pharmacopoeia, 30th ed, p405).
Descriptor Portuguese: Proguanil
Descriptor French: Proguanil
Entry term(s): Bigumal
Chlorguanid
Chloriguane
Chloroguanide
Chloroguanide Hydrochloride
Hydrochloride, Chloroguanide
Hydrochloride, Proguanil
Paludrin
Paludrine
Proguanil Hydrochloride
Tree number(s): D02.078.370.141.710
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D002727
Scope note: A biguanide compound which metabolizes in the body to form cycloguanil, an anti-malaria agent.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Antimalarials
Antimetabolites
Registry Number: S61K3P7B2V
CAS Type 1 Name: Imidodicarbonimidic diamide, N-(4-chlorophenyl)-N'-(1-methylethyl)-
Public MeSH Note: 2011; see CHLOROGUANIDE 1963-2011
History Note: 2011 (1963)
DeCS ID: 2774
Unique ID: D002727
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2011/01/01
Date of Entry: 1999/01/01
Revision Date: 2016/07/05
Proguanil - Preferred
Concept UI M0004166
Scope note A biguanide compound which metabolizes in the body to form cycloguanil, an anti-malaria agent.
Preferred term Proguanil
Entry term(s) Chlorguanid
Chloroguanide
Proguanil Hydrochloride - Narrower
Concept UI M0004168
Preferred term Proguanil Hydrochloride
Entry term(s) Chloroguanide Hydrochloride
Hydrochloride, Chloroguanide
Hydrochloride, Proguanil
Paludrine - Narrower
Concept UI M0004167
Preferred term Paludrine
Entry term(s) Paludrin
Bigumal - Narrower
Concept UI M0350949
Preferred term Bigumal
Chloriguane - Narrower
Concept UI M0350948
Preferred term Chloriguane



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