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Descriptor English: Methotrexate
Descriptor Spanish: Metotrexato
Descriptor Portuguese: Metotrexato
Descriptor French: Méthotrexate
Entry term(s): Amethopterin
Dicesium Salt Methotrexate
Hydrate, Methotrexate
Methotrexate Hydrate
Methotrexate Sodium
Methotrexate, (D)-Isomer
Methotrexate, (DL)-Isomer
Methotrexate, Dicesium Salt
Methotrexate, Disodium Salt
Methotrexate, Sodium Salt
Mexate
Sodium, Methotrexate
Tree number(s): D03.633.100.733.631.192.500
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D008727
Scope note: An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Abortifacient Agents, Nonsteroidal
Antimetabolites, Antineoplastic
Dermatologic Agents
Enzyme Inhibitors
Folic Acid Antagonists
Immunosuppressive Agents
Antirheumatic Agents
Nucleic Acid Synthesis Inhibitors
Registry Number: YL5FZ2Y5U1
CAS Type 1 Name: L-Glutamic acid, N-(4-(((2,4-diamino-6-pteridinyl)methyl)methylamino)benzoyl)-
DeCS ID: 28169
Unique ID: D008727
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1966/01/01
Date of Entry: 1999/01/01
Revision Date: 2016/05/31
Methotrexate - Preferred
Concept UI M0013595
Scope note An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.
Preferred term Methotrexate
Entry term(s) Amethopterin
Methotrexate, (D)-Isomer - Narrower
Concept UI M0330137
Preferred term Methotrexate, (D)-Isomer
Methotrexate, (DL)-Isomer - Narrower
Concept UI M0330138
Preferred term Methotrexate, (DL)-Isomer
Mexate - Narrower
Concept UI M0013596
Preferred term Mexate
Methotrexate Sodium - Narrower
Concept UI M0330136
Preferred term Methotrexate Sodium
Entry term(s) Methotrexate, Disodium Salt
Methotrexate, Sodium Salt
Sodium, Methotrexate
Methotrexate Hydrate - Narrower
Concept UI M0330135
Preferred term Methotrexate Hydrate
Entry term(s) Hydrate, Methotrexate
Methotrexate, Dicesium Salt - Narrower
Concept UI M0330141
Preferred term Methotrexate, Dicesium Salt
Entry term(s) Dicesium Salt Methotrexate



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