DeCS

Descriptor English:

Methotrexate

Descriptor Spanish:

Metotrexato

Spanish from Spain

Descriptor	metotrexato
Entry term(s)	amotopterina
Scope note:	Antimetabolito antineoplásico con propiedades inmunosupresoras. Es un inhibidor de la dihidrofolato reductasa y previene la formación de tetrahidrofolato, necesario para la síntesis de timidilato, un componente esencial del DNA.

Descriptor Portuguese:

Metotrexato

Descriptor French:

Méthotrexate

Entry term(s):

Améthoptérine
Méthylaminoptérine

Tree number(s):

D03.633.100.733.631.192.500

RDF Unique Identifier:

https://id.nlm.nih.gov/mesh/D008727

Scope note:

An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.

Allowable Qualifiers:

AA analogues et dérivés
AD administration et posologie
AE effets indésirables
AG agonistes
AI antagonistes et inhibiteurs
AN analyse
BL sang
CF liquide cérébrospinal
CH composition chimique
CL classification
CS synthèse chimique
EC économie
HI histoire
IM immunologie
IP isolement et purification
ME métabolisme
PD pharmacologie
PK pharmacocinétique
PO intoxication
RE effets des radiations
SD ressources et distribution
ST normes
TO toxicité
TU usage thérapeutique
UR urine

Pharm Action:

Abortifacient Agents, Nonsteroidal
Antimetabolites, Antineoplastic
Dermatologic Agents
Enzyme Inhibitors
Folic Acid Antagonists
Immunosuppressive Agents
Antirheumatic Agents
Nucleic Acid Synthesis Inhibitors

Registry Number:

YL5FZ2Y5U1

CAS Type 1 Name:

L-Glutamic acid, N-(4-(((2,4-diamino-6-pteridinyl)methyl)methylamino)benzoyl)-

DeCS ID:

28169

Unique ID:

D008727

NLM Classification:

QV 269

Documents indexed in the Virtual Health Library (VHL):

Click here to access the VHL documents