| Descriptor English: | Methotrexate | ||||||
| Descriptor Spanish: |
Metotrexato
| ||||||
| Descriptor Portuguese: | Metotrexato | ||||||
| Descriptor French: | Méthotrexate | ||||||
| Entry term(s): |
Amethopterin Dicesium Salt Methotrexate Hydrate, Methotrexate Methotrexate Hydrate Methotrexate Sodium Methotrexate, (D)-Isomer Methotrexate, (DL)-Isomer Methotrexate, Dicesium Salt Methotrexate, Disodium Salt Methotrexate, Sodium Salt Mexate Sodium, Methotrexate |
||||||
| Tree number(s): |
D03.633.100.733.631.192.500 |
||||||
| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D008727 | ||||||
| Scope note: | An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA. |
||||||
| Allowable Qualifiers: |
AA analogs & derivatives AD administration & dosage AE adverse effects AG agonists AI antagonists & inhibitors AN analysis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis EC economics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UR urine |
||||||
| Pharm Action: |
Abortifacient Agents, Nonsteroidal Antimetabolites, Antineoplastic Dermatologic Agents Enzyme Inhibitors Folic Acid Antagonists Immunosuppressive Agents Antirheumatic Agents Nucleic Acid Synthesis Inhibitors |
||||||
| Registry Number: | YL5FZ2Y5U1 | ||||||
| CAS Type 1 Name: | L-Glutamic acid, N-(4-(((2,4-diamino-6-pteridinyl)methyl)methylamino)benzoyl)- | ||||||
| DeCS ID: | 28169 | ||||||
| Unique ID: | D008727 | ||||||
| NLM Classification: | QV 269 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 1966/01/01 | ||||||
| Date of Entry: | 1999/01/01 | ||||||
| Revision Date: | 2016/05/31 |
-
-
CHEMICALS AND DRUGS
Heterocyclic Compounds [D03]Heterocyclic Compounds
|
|
Methotrexate
- Preferred
Methotrexate, (D)-Isomer
- Narrower
Methotrexate, (DL)-Isomer
- Narrower
Mexate
- Narrower
Methotrexate Sodium
- Narrower
Methotrexate Hydrate
- Narrower
Methotrexate, Dicesium Salt
- Narrower
| Concept UI |
M0013595 |
| Scope note | An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA. |
| Preferred term | Methotrexate |
| Entry term(s) |
Amethopterin |
| Concept UI |
M0330137 |
| Preferred term | Methotrexate, (D)-Isomer |
| Concept UI |
M0330138 |
| Preferred term | Methotrexate, (DL)-Isomer |
| Concept UI |
M0013596 |
| Preferred term | Mexate |
| Concept UI |
M0330136 |
| Preferred term | Methotrexate Sodium |
| Entry term(s) |
Methotrexate, Disodium Salt Methotrexate, Sodium Salt Sodium, Methotrexate |
| Concept UI |
M0330135 |
| Preferred term | Methotrexate Hydrate |
| Entry term(s) |
Hydrate, Methotrexate |
| Concept UI |
M0330141 |
| Preferred term | Methotrexate, Dicesium Salt |
| Entry term(s) |
Dicesium Salt Methotrexate |
We want your feedback on the new DeCS / MeSH website
We invite you to complete a survey that will take no more than 3 minutes.
Go to survey
