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Descriptor English: Granulocyte-Macrophage Colony-Stimulating Factor
Descriptor Spanish: Factor Estimulante de Colonias de Granulocitos y Macrófagos
Descriptor factor estimulante de colonias de granulocitos-macrófagos
Entry term(s) CSF-GM
GM-CSF
factor estimulante de las células productoras de histamina
Scope note: Glicoproteína ácida de 23 kDa de PM, con enlaces disulfuro internos. Se produce la proteína en respuesta a numerosos mediadores inflamatorios de las células mesenquimatosas presentes en el ambiente hematopoyético y en sitios periféricos de inflamación. El GM-CSF es capaz de estimular la producción de granulocitos neutrófilos, macrófagos, y de colonias mixtas de granulocitos-macrófagos procedentes de la médula ósea y puede estimular la formación de colonias de eosinófilos a partir de células progenitoras del hígado fetal. El GM-CSF puede estimular también algunas actividades funcionales en los granulocitos maduros y en los macrófagos.
Descriptor Portuguese: Fator Estimulador de Colônias de Granulócitos e Macrófagos
Descriptor French: Facteur de stimulation des colonies de granulocytes et de macrophages
Entry term(s): CSF-2
CSF-GM
Cell-Stimulating Factor, Histamine-Producing
Colony Stimulating Factor, Granulocyte Macrophage
Colony-Stimulating Factor, Granulocyte-Macrophage
GM-CSF
Granulocyte Macrophage Colony Stimulating Factor
Histamine Producing Cell Stimulating Factor
Histamine-Producing Cell-Stimulating Factor
TC-GM-CSF
Tumor Cell Human GM Colony Stimulating Factor
Tumor-Cell Human GM Colony-Stimulating Factor
Tree number(s): D12.644.276.374.410.240.375
D12.776.395.240.300
D12.776.467.374.410.240.375
D23.529.374.410.240.375
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D016178
Scope note: An acidic glycoprotein of MW 23 kDa with internal disulfide bonds. The protein is produced in response to a number of inflammatory mediators by mesenchymal cells present in the hemopoietic environment and at peripheral sites of inflammation. GM-CSF is able to stimulate the production of neutrophilic granulocytes, macrophages, and mixed granulocyte-macrophage colonies from bone marrow cells and can stimulate the formation of eosinophil colonies from fetal liver progenitor cells. GM-CSF can also stimulate some functional activities in mature granulocytes and macrophages.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: 83869-56-1
CAS Type 1 Name: Colony-stimulating factor 2
Previous Indexing: Colony-Stimulating Factors (1976-1990)
Growth Substances (1966-1990)
Interleukin-3 (1981-1987)
Public MeSH Note: 91; HISTAMINE-PRODUCING CELL-STIMULATING FACTOR was HISTAMINE-PRODUCING CELL STIMULATING FACTOR see INTERLEUKIN-3 1987-91
Online Note: use INTERLEUKIN-3 to search HISTAMINE-PRODUCING CELL-STIMULATING FACTOR 1987-91
History Note: 91; HISTAMINE-PRODUCING CELL-STIMULATING FACTOR was HISTAMINE-PRODUCING CELL STIMULATING FACTOR see INTERLEUKIN-3 1987-91
Entry Version: GMCSF
Related: Receptors, Granulocyte-Macrophage Colony-Stimulating Factor MeSH
DeCS ID: 28969
Unique ID: D016178
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1991/01/01
Date of Entry: 1990/06/19
Revision Date: 2006/07/05
Granulocyte-Macrophage Colony-Stimulating Factor - Preferred
Concept UI M0024695
Scope note An acidic glycoprotein of MW 23 kDa with internal disulfide bonds. The protein is produced in response to a number of inflammatory mediators by mesenchymal cells present in the hemopoietic environment and at peripheral sites of inflammation. GM-CSF is able to stimulate the production of neutrophilic granulocytes, macrophages, and mixed granulocyte-macrophage colonies from bone marrow cells and can stimulate the formation of eosinophil colonies from fetal liver progenitor cells. GM-CSF can also stimulate some functional activities in mature granulocytes and macrophages.
Preferred term Granulocyte-Macrophage Colony-Stimulating Factor
Entry term(s) CSF-2
CSF-GM
Cell-Stimulating Factor, Histamine-Producing
Colony Stimulating Factor, Granulocyte Macrophage
Colony-Stimulating Factor, Granulocyte-Macrophage
GM-CSF
Granulocyte Macrophage Colony Stimulating Factor
Histamine Producing Cell Stimulating Factor
Histamine-Producing Cell-Stimulating Factor
TC-GM-CSF
Tumor Cell Human GM Colony Stimulating Factor
Tumor-Cell Human GM Colony-Stimulating Factor



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