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Descriptor English: Macrophage Colony-Stimulating Factor
Descriptor Spanish: Factor Estimulante de Colonias de Macrófagos
Descriptor factor estimulante de colonias de macrófagos
Entry term(s) CSF-1
CSF-M
M-CSF
factor 1 de estimulación de colonias
Scope note: Factor estimulante de colonias de fagocitos mononucleares (M-CSF) sintetizado por células mesenquimatosas. El compuesto estimula la supervivencia, proliferación y diferenciación de las células hematopoyéticas de la serie monocito-macrófago. El M-CSF es un dímero glucoproteico con enlaces disulfuro con un PM de 70 kDa. Se une a un receptor específico con alta afinidad (RECEPTOR, FACTOR ESTIMULANTE DE COLONIAS DE MACRÓFAGOS).
Descriptor Portuguese: Fator Estimulador de Colônias de Macrófagos
Descriptor French: Facteur de stimulation des colonies de macrophages
Entry term(s): CSF-1
CSF-M
Colony Stimulating Factor 1
Colony Stimulating Factor, Macrophage
Colony-Stimulating Factor 1
Colony-Stimulating Factor, Macrophage
M-CSF
Tree number(s): D09.400.430.775.500
D12.644.276.374.410.240.500
D12.776.395.240.500
D12.776.467.374.410.240.500
D23.529.374.410.240.500
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D016173
Scope note: A mononuclear phagocyte colony-stimulating factor (M-CSF) synthesized by mesenchymal cells. The compound stimulates the survival, proliferation, and differentiation of hematopoietic cells of the monocyte-macrophage series. M-CSF is a disulfide-bonded glycoprotein dimer with a MW of 70 kDa. It binds to a specific high affinity receptor (RECEPTOR, MACROPHAGE COLONY-STIMULATING FACTOR).
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: 81627-83-0
CAS Type 1 Name: Colony-stimulating factor 1
Previous Indexing: Colony-Stimulating Factors (1976-1990)
Public MeSH Note: 91
History Note: 91
Entry Version: MCSF
Related: Receptor, Macrophage Colony-Stimulating Factor MeSH
DeCS ID: 29035
Unique ID: D016173
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1991/01/01
Date of Entry: 1990/06/19
Revision Date: 2006/07/05
Macrophage Colony-Stimulating Factor - Preferred
Concept UI M0024689
Scope note A mononuclear phagocyte colony-stimulating factor (M-CSF) synthesized by mesenchymal cells. The compound stimulates the survival, proliferation, and differentiation of hematopoietic cells of the monocyte-macrophage series. M-CSF is a disulfide-bonded glycoprotein dimer with a MW of 70 kDa. It binds to a specific high affinity receptor (RECEPTOR, MACROPHAGE COLONY-STIMULATING FACTOR).
Preferred term Macrophage Colony-Stimulating Factor
Entry term(s) CSF-1
CSF-M
Colony Stimulating Factor 1
Colony Stimulating Factor, Macrophage
Colony-Stimulating Factor 1
Colony-Stimulating Factor, Macrophage
M-CSF



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