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Descriptor English: Epoprostenol
Descriptor Spanish: Epoprostenol
Descriptor Portuguese: Epoprostenol
Descriptor French: Prostacycline
Entry term(s): Epoprostanol
Epoprostenol Sodium
Epoprostenol Sodium Salt, (5Z,9alpha,11alpha,13E,15S)-Isomer
Flolan
Prostacyclin
Prostaglandin I(2)
Prostaglandin I2
Veletri
Tree number(s): D10.251.355.255.550.550.500
D23.469.050.175.725.550.500
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D011464
Scope note: A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from PROSTAGLANDIN ENDOPEROXIDES in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension (HYPERTENSION, PULMONARY).
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Antihypertensive Agents
Platelet Aggregation Inhibitors
Registry Number: DCR9Z582X0
CAS Type 1 Name: Prosta-5,13-dien-1-oic acid, 6,9-epoxy-11,15-dihydroxy-, (5Z,9alpha,11alpha,13E,15S)-
Previous Indexing: Prostaglandins (1966-1977)
Public MeSH Note: 1991; see PROSTAGLANDINS X 1978-1990; for PROSTACYCLIN see PROSTACYCLINS 1978-1993; for PROSTAGLANDIN I2 see PROSTAGLANDINS I2 1982-1993; for PROSTAGLANDIN X see PROSTAGLANDINS X 1991-1993
History Note: 1991 (1978); use PROSTAGLANDINS X 1978-1990; for PROSTACYCLIN use PROSTACYCLINS 1978-1993; for PROSTAGLANDIN I2 use PROSTAGLANDINS I2 1982-1993; for PROSTAGLANDIN X use PROSTAGLANDINS X 1991-1993
DeCS ID: 29280
Unique ID: D011464
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1984/01/01
Date of Entry: 1977/05/23
Revision Date: 2018/03/01
Epoprostenol - Preferred
Concept UI M0017816
Scope note A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from PROSTAGLANDIN ENDOPEROXIDES in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension (HYPERTENSION, PULMONARY).
Preferred term Epoprostenol
Entry term(s) Epoprostanol
Prostacyclin
Prostaglandin I(2)
Prostaglandin I2
Veletri - Narrower
Concept UI M0446737
Preferred term Veletri
Epoprostenol Sodium - Narrower
Concept UI M0017819
Preferred term Epoprostenol Sodium
Entry term(s) Epoprostenol Sodium Salt, (5Z,9alpha,11alpha,13E,15S)-Isomer
Flolan - Narrower
Concept UI M0017820
Preferred term Flolan



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