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Descriptor English: ISCOMs
Descriptor Spanish: ISCOMs
Descriptor ISCOMs
Entry term(s) complejos inmunoestimulantes
Scope note: Formulación que se utiliza para presentar un antígeno a fin de inducir respuestas inmunológicas específicas. Está constituida por un ensamblaje de antígenos en forma multimérica. Este ensamblaje se une a una matriz con un adyuvante acoplado, la saponina. Los complejos inmunoestimulantes (ISCOM) inducen intensas respuestas de anticuerpos en el suero, y se usan como formas muy inmunógenas de vacunas de subunidades.
Descriptor Portuguese: ISCOMs
Descriptor French: Complexes immunostimulants
Entry term(s): Complexes, Immuno-Stimulating
Complexes, Immunostimulating
ISCOM
Immuno Stimulating Complexes
Immuno-Stimulating Complexes
Immunostimulating Complexes
Tree number(s): D20.215.894.860.449
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D016882
Scope note: A formulation for presenting an antigen to induce specific immunologic responses. It consists of an assembly of antigens in multimeric form. The assembly is attached to a matrix with a built-in adjuvant, saponin. ISCOMs induce strong serum antibody responses, and are used as highly immunogenic forms of subunit vaccines.
Annotation: coord IM with specific type of vaccine (IM or NIM)
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
DE drug effects
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PO poisoning
RE radiation effects
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Pharm Action: Adjuvants, Immunologic
Previous Indexing: Adjuvants, Immunologic (1985-1991)
Viral Vaccines (1985-1991)
Public MeSH Note: 92
History Note: 92
Related: Saponins MeSH
DeCS ID: 30027
Unique ID: D016882
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1992/01/01
Date of Entry: 1991/08/17
Revision Date: 2005/06/30
ISCOMs - Preferred
Concept UI M0025686
Scope note A formulation for presenting an antigen to induce specific immunologic responses. It consists of an assembly of antigens in multimeric form. The assembly is attached to a matrix with a built-in adjuvant, saponin. ISCOMs induce strong serum antibody responses, and are used as highly immunogenic forms of subunit vaccines.
Preferred term ISCOMs
Entry term(s) Complexes, Immuno-Stimulating
Complexes, Immunostimulating
ISCOM
Immuno Stimulating Complexes
Immuno-Stimulating Complexes
Immunostimulating Complexes



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