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Descriptor English: Tacrolimus
Descriptor Spanish: Tacrolimus
Descriptor tacrólimus
Entry term(s) FK-506
tacrolimus
Scope note: Macrólido aislado del caldo de cultivo de una cepa de Streptomyces tsukubaensis que tiene una potente actividad inmunosupresora in vivo y previene la activación de los linfocitos T en respuesta a la estimulación antigénica o mitogénica in vitro.
Descriptor Portuguese: Tacrolimo
Descriptor French: Tacrolimus
Entry term(s): Anhydrous Tacrolimus
Anhydrous, Tacrolimus
FK 506
FK-506
FK506
FR 900506
FR-900506
FR900506
Prograf
Prograft
Tacrolimus Anhydrous
Tacrolimus, Anhydrous
Tree number(s): D02.540.505.810
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D016559
Scope note: A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation in vitro.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Immunosuppressive Agents
Calcineurin Inhibitors
Registry Number: WM0HAQ4WNM
CAS Type 1 Name: 15,19-Epoxy-3H-pyrido(2,1-c)(1,4)oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-(2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl)-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-, monohydrate, (3S-(3R*(E(1S*,3S*,4S*)),4S*,5R*,8S*,9E,12R*,14R*,15S*,16R*,18S*,19S*,26aR*))-
Previous Indexing: Antibiotics, Macrolide (1987-1991)
Immunosuppressive Agents (1987-1991)
Public MeSH Note: 96; was FK-506 1992-95; FK-506 was indexed under ANTIBIOTICS, MACROLIDE 1989-91 & PYRIDINES 1987-89
Online Note: use TACROLIMUS (NM) to search FK-506 1987-91
History Note: 96; was FK-506 1992-95, was FK 506 (NM) 1987-91
DeCS ID: 30103
Unique ID: D016559
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1992/01/01
Date of Entry: 1991/04/24
Revision Date: 2016/07/01
Tacrolimus - Preferred
Concept UI M0025261
Scope note A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation in vitro.
Preferred term Tacrolimus
Prograf - Narrower
Concept UI M0025262
Preferred term Prograf
Entry term(s) Prograft
FR-900506 - Narrower
Concept UI M0335295
Preferred term FR-900506
Entry term(s) FR 900506
FR900506
Anhydrous Tacrolimus - Narrower
Concept UI M0329463
Preferred term Anhydrous Tacrolimus
Entry term(s) Anhydrous, Tacrolimus
Tacrolimus Anhydrous
Tacrolimus, Anhydrous
FK-506 - Narrower
Concept UI M0335288
Preferred term FK-506
Entry term(s) FK 506
FK506



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