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Descriptor English: Oligomycins
Descriptor Spanish: Oligomicinas
Descriptor oligomicinas
Scope note: Grupo estrechamente relacionado de sustancias tóxicas elaboradas por varias cepas de Streptomyces. Son macrólidos de 26 miembros con partes de lactona y doble enlaces e inhiben varias ATPasas, ocasionando un desacoplamiento de la fosforilación de la respiración mitocondrial. Son utilizadas como herramienta en citoquímica. Algunas oligomicinas específicas son la RUTAMICINA, peliomicina y botricidina (antiguamente venturicidina X).
Descriptor Portuguese: Oligomicinas
Descriptor French: Oligomycines
Entry term(s): Oligomycin
Tree number(s): D02.540.505.620
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D009840
Scope note: A closely related group of toxic substances elaborated by various strains of Streptomyces. They are 26-membered macrolides with lactone moieties and double bonds and inhibit various ATPases, causing uncoupling of phosphorylation from mitochondrial respiration. Used as tools in cytochemistry. Some specific oligomycins are RUTAMYCIN, peliomycin, and botrycidin (formerly venturicidin X).
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Anti-Bacterial Agents
Enzyme Inhibitors
Uncoupling Agents
Public MeSH Note: 82; was OLIGOMYCIN 1966-81; RUTAMYCIN was see under ANTIBIOTICS, ANTIFUNGAL 1975-81
Online Note: use OLIGOMYCINS to search OLIGOMYCIN 1966-81
History Note: 82; was OLIGOMYCIN 1963-81 (Prov 1963-65)
DeCS ID: 10026
Unique ID: D009840
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1966/01/01
Date of Entry: 1999/01/01
Revision Date: 2011/06/24
Oligomycins - Preferred
Concept UI M0015277
Scope note A closely related group of toxic substances elaborated by various strains of Streptomyces. They are 26-membered macrolides with lactone moieties and double bonds and inhibit various ATPases, causing uncoupling of phosphorylation from mitochondrial respiration. Used as tools in cytochemistry. Some specific oligomycins are RUTAMYCIN, peliomycin, and botrycidin (formerly venturicidin X).
Preferred term Oligomycins
Entry term(s) Oligomycin



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