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Descriptor English: Aflatoxin M1
Descriptor Spanish: Aflatoxina M1
Descriptor aflatoxina M1
Entry term(s) aflatoxina M(1)
Scope note: Metabolito 4-hidroxilado de la AFLATOXINA B1, una de las MICOTOXINAS de los alimentos contaminados por ASPERGILLUS. Está asociado con lesiones hepáticas y cáncer de HÍGADO resultantes de la activación del P450 al epóxido que alquila el ADN. La toxicidad depende del equilibrio entre las enzimas hepáticas que lo activan (CITOCROMO P-450) y otras que lo contrarrestan (GLUTATIÓN S- TRANSFERASA) (Pharmac Ther 50.443 1991). Los primates y la rata son sensibles, mientras que el ratón y el hámster lo toleran (Canc Res 29.236 1969).
Descriptor Portuguese: Aflatoxina M1
Descriptor French: Aflatoxine M1
Entry term(s): 4 Hydroxyaflatoxin B1
4-Hydroxyaflatoxin B1
Aflatoxin M
Aflatoxin M(1)
Aflatoxin M1, cis(+-)-Isomer
Tree number(s): D03.383.663.283.119.100
D03.633.100.150.119.100
D23.946.587.142.100
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D016607
Scope note: A 4-hydroxylated metabolite of AFLATOXIN B1, one of the MYCOTOXINS from ASPERGILLUS tainted food. It is associated with LIVER damage and cancer resulting from its P450 activation to the epoxide which alkylates DNA. Toxicity depends on the balance of liver enzymes that activate it (CYTOCHROME P-450) and others that detoxify it (GLUTATHIONE S TRANSFERASE) (Pharmac Ther 50.443 1991). Primates & rat are sensitive while mouse and hamster are tolerant (Canc Res 29.236 1969).
Annotation: /antag permitted but consider also ANTITOXINS
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Poisons
Registry Number: 6795-23-9
CAS Type 1 Name: Cyclopenta(c)furo(3',2':4,5)furo(2,3-h)(1)benzopyran-1,11-dione, 2,3,6a,9a-tetrahydro-9a-hydroxy-4-methoxy-, (6aR-cis)-
Previous Indexing: Aflatoxins (1969-1991)
Public MeSH Note: 92; AFLATOXIN M1 was indexed under AFLATOXINS 1980-91
Online Note: use AFLATOXIN M1 (NM) to search AFLATOXIN M1 1979-91
History Note: 92; was AFLATOXIN (NM) 1980-91
Entry Version: AFM1
DeCS ID: 30276
Unique ID: D016607
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1992/01/01
Date of Entry: 1991/01/25
Revision Date: 2020/05/27
Aflatoxin M1 - Preferred
Concept UI M0025324
Scope note A 4-hydroxylated metabolite of AFLATOXIN B1, one of the MYCOTOXINS from ASPERGILLUS tainted food. It is associated with LIVER damage and cancer resulting from its P450 activation to the epoxide which alkylates DNA. Toxicity depends on the balance of liver enzymes that activate it (CYTOCHROME P-450) and others that detoxify it (GLUTATHIONE S TRANSFERASE) (Pharmac Ther 50.443 1991). Primates & rat are sensitive while mouse and hamster are tolerant (Canc Res 29.236 1969).
Preferred term Aflatoxin M1
Entry term(s) 4 Hydroxyaflatoxin B1
4-Hydroxyaflatoxin B1
Aflatoxin M(1)
Aflatoxin M1, cis(+-)-Isomer - Narrower
Concept UI M0331348
Preferred term Aflatoxin M1, cis(+-)-Isomer
Aflatoxin M - Broader
Concept UI M0025325
Preferred term Aflatoxin M



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