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Descriptor English: Thiotepa
Descriptor Spanish: Tiotepa
Descriptor Portuguese: Tiotepa
Descriptor French: Thiotépa
Entry term(s): AI3 24916
AI3-24916
AI324916
Girostan
NSC 6396
NSC-6396
NSC6396
Tespa
Tespamin
Thio Tepa
Thio-Tepa
Thiophosphamide
Triethylenethiophosphoramide
Tris(1-aziridinyl)phosphine Sulfide
Tree number(s): D02.705.672.875
D03.383.097.217.935.960
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D013852
Scope note: A very toxic alkylating antineoplastic agent also used as an insect sterilant. It causes skin, gastrointestinal, CNS, and bone marrow damage. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), thiotepa may reasonably be anticipated to be a carcinogen (Merck Index, 11th ed).
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Antineoplastic Agents, Alkylating
Myeloablative Agonists
Registry Number: 905Z5W3GKH
CAS Type 1 Name: Aziridine, 1,1',1''-phosphinothioylidynetris-
Public MeSH Note: 92; was THIO-TEPA 1963-91; THIOTEPA was see THIO-TEPA 1977-91
Online Note: use THIOTEPA to search THIO-TEPA 1966-91
History Note: 92; was THIO-TEPA 1963-91; THIOTEPA was see THIO-TEPA 1977-91
DeCS ID: 30423
Unique ID: D013852
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1992/01/01
Date of Entry: 1999/01/01
Revision Date: 2016/06/01
Thiotepa - Preferred
Concept UI M0021343
Scope note A very toxic alkylating antineoplastic agent also used as an insect sterilant. It causes skin, gastrointestinal, CNS, and bone marrow damage. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), thiotepa may reasonably be anticipated to be a carcinogen (Merck Index, 11th ed).
Preferred term Thiotepa
Entry term(s) Thio Tepa
Thio-Tepa
Thiophosphamide
Triethylenethiophosphoramide
Tris(1-aziridinyl)phosphine Sulfide
Tespamin - Narrower
Concept UI M0352204
Preferred term Tespamin
NSC-6396 - Narrower
Concept UI M0352206
Preferred term NSC-6396
Entry term(s) NSC 6396
NSC6396
Tespa - Narrower
Concept UI M0352205
Preferred term Tespa
AI3-24916 - Narrower
Concept UI M0352208
Preferred term AI3-24916
Entry term(s) AI3 24916
AI324916
Girostan - Narrower
Concept UI M0352207
Preferred term Girostan



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