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Descriptor English: Superantigens
Descriptor Spanish: Superantígenos
Descriptor Portuguese: Superantígenos
Descriptor French: Superantigènes
Tree number(s): D23.050.820
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D018089
Scope note: Microbial antigens that have in common an extremely potent activating effect on T-cells that bear a specific variable region. Superantigens cross-link the variable region with class II MHC proteins regardless of the peptide binding in the T-cell receptor's pocket. The result is a transient expansion and subsequent death and anergy of the T-cells with the appropriate variable regions.
Annotation: coordinate IM with specific microbe /immunol (IM); for interaction of superantigens with endotoxins, coordinate with ENDOTOXINS or specifics
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
DE drug effects
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PO poisoning
RE radiation effects
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: specific antigens (1989-1993)
Public MeSH Note: 94
History Note: 94
Related: Apoptosis MeSH
Clonal Anergy MeSH
Receptors, Antigen, T-Cell, alpha-beta MeSH
DeCS ID: 31023
Unique ID: D018089
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1994/01/01
Date of Entry: 1993/07/01
Revision Date: 2007/07/09
Superantigens - Preferred
Concept UI M0027285
Scope note Microbial antigens that have in common an extremely potent activating effect on T-cells that bear a specific variable region. Superantigens cross-link the variable region with class II MHC proteins regardless of the peptide binding in the T-cell receptor's pocket. The result is a transient expansion and subsequent death and anergy of the T-cells with the appropriate variable regions.
Preferred term Superantigens



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