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Descriptor English: PrPC Proteins
Descriptor Spanish: Proteínas PrPC
Descriptor proteínas PrPC
Entry term(s) proteína precursora de amiloide de Scrapie
Scope note: Isoforma celular normal de las PROTEÍNAS PRIÓNICAS codificada por un gen cromosómico y que se encuentra en el tejido cerebral normal y en el tejido cerebral afectado por tembladera, y en otros tejidos normales. Las PrPC son proteínas sensibles a la proteasa cuya función es desconocida. La modificación postranslacional de las PrPC en PrPSC provoca la infectividad.
Descriptor Portuguese: Proteínas PrPC
Descriptor French: Protéines PrPC
Entry term(s): Cp 33-35
Cp33-35, Scrapie
PrP sen
PrP-sen
Scrapie Amyloid Precursor Protein
Tree number(s): D12.776.785.340.500
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D018621
Scope note: Normal cellular isoform of PRION PROTEINS encoded by a chromosomal gene and found in normal and scrapie-infected brain tissue, and other normal tissue. PrPC are protease-sensitive proteins whose function is unknown. Posttranslational modification of PrPC into PrPSC leads to infectivity.
Annotation: PrPC stands for PRion Protein Cellular; do not confuse with PRPSC PROTEINS which are scrapie prion proteins
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
PY pathogenicity
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: Prions (1992-1994)
Public MeSH Note: 95; SCRAPIE AMYLOID PRECURSOR PROTEIN was indexed under PRIONS & PROTEIN PRECURSORS 1992-94 and under VIRAL PROTEINS 1989-91
Online Note: use PRPC PROTEINS (NM) to search SCRAPIE AMYLOID PRECURSOR PROTEIN 1989-94
History Note: 95; SCRAPIE AMYLOID PRECURSOR PROTEIN was NM 1989-94
Entry Version: PRPC
DeCS ID: 32060
Unique ID: D018621
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1995/01/01
Date of Entry: 1994/04/16
Revision Date: 2016/06/13
PrPC Proteins - Preferred
Concept UI M0027910
Scope note Normal cellular isoform of PRION PROTEINS encoded by a chromosomal gene and found in normal and scrapie-infected brain tissue, and other normal tissue. PrPC are protease-sensitive proteins whose function is unknown. Posttranslational modification of PrPC into PrPSC leads to infectivity.
Preferred term PrPC Proteins
Entry term(s) Cp 33-35
Cp33-35, Scrapie
PrP sen
PrP-sen
Scrapie Amyloid Precursor Protein



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