Search
Descriptor English: Multiple Endocrine Neoplasia Type 1
Descriptor Spanish: Neoplasia Endocrina Múltiple Tipo 1
Descriptor neoplasia endocrina múltiple tipo 1
Entry term(s) NEM 1
síndrome de Wermer
Scope note: Síndrome poco frecuente caracterizado por hiperplasia y/o neoplasia de la hipófisis, glándulas paratiroideas, e islotes pancreáticos. En el 90 por ciento de los casos hay hiperparatiroidismo que generalmente es la primera manifestación del síndrome. La manifestación pancreática más frecuente es el gastrinoma que produce típicamente Síndrome de Zollinger-Ellison. La aparición de esté síndrome ha sido limitada a la pérdida de la heterocigosidad alélica del locus 11q13 en el brazo largo del cromosoma 11. Los pacientes, en conjunto, muestran largos períodos de supervivencia. La quimioterapia se utiliza con poca frecuencia y el tratamiento quirúrgico generalmente depende de la expresión genética en cada paciente individualizado. (Traducción libre del original: Holland et al., Cancer Medicine, 3d ed, pp1169-72)
Descriptor Portuguese: Neoplasia Endócrina Múltipla Tipo 1
Descriptor French: Néoplasie endocrinienne multiple de type 1
Entry term(s): Multiple Endocrine Neoplasia Type I
Multiple Endocrine Neoplasms Type 1
Neoplasia, Multiple Endocrine Type 1
Neoplasms, Multiple Endocrine Type 1
Neoplasms, Multiple Endocrine Type I
Wermer Syndrome
Tree number(s): C04.588.322.400.500
C04.651.600.500
C04.700.630.500
C16.320.700.630.500
C19.344.400.500
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D018761
Scope note: A form of multiple endocrine neoplasia that is characterized by the combined occurrence of tumors in the PARATHYROID GLANDS, the PITUITARY GLAND, and the PANCREATIC ISLETS. The resulting clinical signs include HYPERPARATHYROIDISM; HYPERCALCEMIA; HYPERPROLACTINEMIA; CUSHING DISEASE; GASTRINOMA; and ZOLLINGER-ELLISON SYNDROME. This disease is due to loss-of-function of the MEN1 gene, a tumor suppressor gene (GENES, TUMOR SUPPRESSOR) on CHROMOSOME 11 (Locus: 11q13).
Annotation: coordinate IM with specific endocrine/neoplasm pre-coordinates (IM) + specific histological type (IM) if pertinent
Allowable Qualifiers: BL blood
BS blood supply
CF cerebrospinal fluid
CH chemistry
CI chemically induced
CL classification
CN congenital
CO complications
DG diagnostic imaging
DH diet therapy
DI diagnosis
DT drug therapy
EC economics
EH ethnology
EM embryology
EN enzymology
EP epidemiology
ET etiology
GE genetics
HI history
IM immunology
ME metabolism
MI microbiology
MO mortality
NU nursing
PA pathology
PC prevention & control
PP physiopathology
PS parasitology
PX psychology
RH rehabilitation
RT radiotherapy
SC secondary
SU surgery
TH therapy
UL ultrastructure
UR urine
VE veterinary
VI virology
Previous Indexing: Multiple Endocrine Neoplasia (1972-1994)
Public MeSH Note: 95; MEA I, MEN I, & WERMER SYNDROME were see NEOPLASMS, MULTIPLE ENDOCRINE 1983-94
Online Note: use MULTIPLE ENDOCRINE NEOPLASIA to search MEA I, MEN I, & WERMER SYNDROME 1983-94
History Note: 95; MEA I, MEN I, & WERMER SYNDROME were see NEOPLASMS, MULTIPLE ENDOCRINE 1983-94
Entry Version: MULTIPLE ENDOCRINE NEOPL TYPE 1
DeCS ID: 32134
Unique ID: D018761
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1995/01/01
Date of Entry: 1994/05/23
Revision Date: 2017/02/24
Multiple Endocrine Neoplasia Type 1 - Preferred
Concept UI M0028096
Scope note A form of multiple endocrine neoplasia that is characterized by the combined occurrence of tumors in the PARATHYROID GLANDS, the PITUITARY GLAND, and the PANCREATIC ISLETS. The resulting clinical signs include HYPERPARATHYROIDISM; HYPERCALCEMIA; HYPERPROLACTINEMIA; CUSHING DISEASE; GASTRINOMA; and ZOLLINGER-ELLISON SYNDROME. This disease is due to loss-of-function of the MEN1 gene, a tumor suppressor gene (GENES, TUMOR SUPPRESSOR) on CHROMOSOME 11 (Locus: 11q13).
Preferred term Multiple Endocrine Neoplasia Type 1
Entry term(s) Multiple Endocrine Neoplasia Type I
Multiple Endocrine Neoplasms Type 1
Neoplasia, Multiple Endocrine Type 1
Neoplasms, Multiple Endocrine Type 1
Neoplasms, Multiple Endocrine Type I
Wermer Syndrome



We want your feedback on the new DeCS / MeSH website

We invite you to complete a survey that will take no more than 3 minutes.


Go to survey