| Descriptor English: | Complement Pathway, Classical | ||||||
| Descriptor Spanish: |
Vía Clásica del Complemento
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| Descriptor Portuguese: | Via Clássica do Complemento | ||||||
| Descriptor French: | Voie classique d'activation du complément | ||||||
| Entry term(s): |
Classical Complement Activation Pathway Classical Complement Pathway Complement Activation Pathway, Classical |
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| Tree number(s): |
G12.274.698 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D003171 | ||||||
| Scope note: | Complement activation initiated by the binding of COMPLEMENT C1 to ANTIGEN-ANTIBODY COMPLEXES at the COMPLEMENT C1Q subunit. This leads to the sequential activation of COMPLEMENT C1R and COMPLEMENT C1S subunits. Activated C1s cleaves COMPLEMENT C4 and COMPLEMENT C2 forming the membrane-bound classical C3 CONVERTASE (C4B2A) and the subsequent C5 CONVERTASE (C4B2A3B) leading to cleavage of COMPLEMENT C5 and the assembly of COMPLEMENT MEMBRANE ATTACK COMPLEX. |
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| Allowable Qualifiers: |
DE drug effects ES ethics GE genetics IM immunology PH physiology RE radiation effects |
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| Previous Indexing: |
Complement (1966-1978) Complement Fixation Tests (1966-1978) |
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| Public MeSH Note: | 91; was see under COMPLEMENT ACTIVATION 1979-90 |
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| History Note: | 91(79); was see under COMPLEMENT ACTIVATION 1979-90 |
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| DeCS ID: | 3217 | ||||||
| Unique ID: | D003171 | ||||||
| NLM Classification: | QW 680 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 1991/01/01 | ||||||
| Date of Entry: | 1977/12/02 | ||||||
| Revision Date: | 2016/06/23 |
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PHENOMENA AND PROCESSES
Immune System Phenomena [G12]Immune System Phenomena
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Complement Pathway, Classical
- Preferred
| Concept UI |
M0004923 |
| Scope note | Complement activation initiated by the binding of COMPLEMENT C1 to ANTIGEN-ANTIBODY COMPLEXES at the COMPLEMENT C1Q subunit. This leads to the sequential activation of COMPLEMENT C1R and COMPLEMENT C1S subunits. Activated C1s cleaves COMPLEMENT C4 and COMPLEMENT C2 forming the membrane-bound classical C3 CONVERTASE (C4B2A) and the subsequent C5 CONVERTASE (C4B2A3B) leading to cleavage of COMPLEMENT C5 and the assembly of COMPLEMENT MEMBRANE ATTACK COMPLEX. |
| Preferred term | Complement Pathway, Classical |
| Entry term(s) |
Classical Complement Activation Pathway Classical Complement Pathway Complement Activation Pathway, Classical |
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