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Descriptor English: Gene Dosage
Descriptor Spanish: Dosificación de Gen
Descriptor dosificación génica
Entry term(s) dosificación de genes
dosis de genes
dosis génica
número de copias génicas
Scope note: Número de copias de un determinado gen presentes en una célula de un organismo. El incremento de la dosificación de un gen (por ejemplo, por DUPLICACIÓN GÉNICA) puede dar lugar a mayor formación del producto del gen. Cuando hay cambios o diferencias de la dosificación de gen los mecanismos de COMPENSACIÓN DE DOSIS GENÉTICA producen ajustes hasta la cuantía de la EXPRESIÓN GÉNICA.
Descriptor Portuguese: Dosagem de Genes
Descriptor French: Dosage génique
Entry term(s): Copy Number, Gene
Copy Numbers, Gene
Dosage, Gene
Dosages, Gene
Gene Copy Number
Gene Copy Numbers
Gene Dosages
Number, Gene Copy
Numbers, Gene Copy
Tree number(s): G05.380.350
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D018628
Scope note: The number of copies of a given gene present in the cell of an organism. An increase in gene dosage (by GENE DUPLICATION for example) can result in higher levels of gene product formation. GENE DOSAGE COMPENSATION mechanisms result in adjustments to the level GENE EXPRESSION when there are changes or differences in gene dosage.
Annotation: do not confuse with DOSAGE COMPENSATION, GENETIC
Allowable Qualifiers: DE drug effects
GE genetics
IM immunology
PH physiology
RE radiation effects
Public MeSH Note: 95
History Note: 95
Related: DNA Copy Number Variations MeSH
DeCS ID: 32234
Unique ID: D018628
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1995/01/01
Date of Entry: 1994/04/16
Revision Date: 2009/07/06
Gene Dosage - Preferred
Concept UI M0027921
Scope note The number of copies of a given gene present in the cell of an organism. An increase in gene dosage (by GENE DUPLICATION for example) can result in higher levels of gene product formation. GENE DOSAGE COMPENSATION mechanisms result in adjustments to the level GENE EXPRESSION when there are changes or differences in gene dosage.
Preferred term Gene Dosage
Entry term(s) Copy Number, Gene
Copy Numbers, Gene
Dosage, Gene
Dosages, Gene
Gene Copy Number
Gene Copy Numbers
Gene Dosages
Number, Gene Copy
Numbers, Gene Copy



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