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Descriptor English: Phosphatidylinositol 4,5-Diphosphate
Descriptor Spanish: Fosfatidilinositol 4,5-Difosfato
Descriptor fosfatidilinositol 4,5-difosfato
Entry term(s) PIP2
fosfatidilinositol-4,5-bifosfato
Scope note: Fosfoinosítido presente en todas las células eucarióticas, sobre todo en la membrana plasmática. Es el principal substrato para la fosfoinositidasa C estimulada por receptores, con la posterior formación de inositol 1,4,5-trifosfato y diacilglicerol y probablemente también para la inositol fosfolípidos 3 cinasa estimulada por receptores. (Kendrew, The Encyclopedia of Molecular Biology, 1994)
Descriptor Portuguese: Fosfatidilinositol 4,5-Difosfato
Descriptor French: Phosphatidylinositol diphosphate-4,5
Entry term(s): 4,5-Biphosphate, Phosphatidylinositol
4,5-Diphosphate, Phosphatidylinositol
Phosphatidylinositol 4,5 Biphosphate
Phosphatidylinositol 4,5 Diphosphate
Phosphatidylinositol 4,5-Biphosphate
Phosphatidylinositol Phosphate, PtdIns(4,5)P2
Phosphatidylinositol-4,5-Biphosphate
PtIns 4,5-P2
PtdIns(4,5)P2
PtdInsP
PtdInsP2
Tree number(s): D10.570.755.375.760.400.942.625.900
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D019269
Scope note: A phosphoinositide present in all eukaryotic cells, particularly in the plasma membrane. It is the major substrate for receptor-stimulated phosphoinositidase C, with the consequent formation of inositol 1,4,5-triphosphate and diacylglycerol, and probably also for receptor-stimulated inositol phospholipid 3-kinase. (Kendrew, The Encyclopedia of Molecular Biology, 1994)
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Previous Indexing: Phosphatidylinositol Phosphates (1994-1996)
Phosphatidylinositols (1981-1993)
Public MeSH Note: 97; PHOSPHATIDYLINOSITOL 4,5-DIPHOSPHATE was indexed under PHOSPHATIDYLINOSITOL PHOSPHATES 1994-96 & PHOSPHOINOSITIDES 1981-93
Online Note: use PHOSPHATIDYLINOSITOL 4,5-DIPHOSPHATE (NM) to search PHOSPHATIDYLINOSITOL 4,5-DIPHOSPHATE 1981-96
History Note: 97; see PHOSPHATIDYLINOSITOL 4,5-DIPHOSPHATE (NM) 1981-96
DeCS ID: 33029
Unique ID: D019269
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1997/01/01
Date of Entry: 1996/06/10
Revision Date: 2010/06/25
Phosphatidylinositol 4,5-Diphosphate - Preferred
Concept UI M0028698
Scope note A phosphoinositide present in all eukaryotic cells, particularly in the plasma membrane. It is the major substrate for receptor-stimulated phosphoinositidase C, with the consequent formation of inositol 1,4,5-triphosphate and diacylglycerol, and probably also for receptor-stimulated inositol phospholipid 3-kinase. (Kendrew, The Encyclopedia of Molecular Biology, 1994)
Preferred term Phosphatidylinositol 4,5-Diphosphate
Entry term(s) 4,5-Biphosphate, Phosphatidylinositol
4,5-Diphosphate, Phosphatidylinositol
Phosphatidylinositol 4,5 Biphosphate
Phosphatidylinositol 4,5 Diphosphate
Phosphatidylinositol 4,5-Biphosphate
Phosphatidylinositol Phosphate, PtdIns(4,5)P2
Phosphatidylinositol-4,5-Biphosphate
PtIns 4,5-P2
PtdIns(4,5)P2
PtdInsP
PtdInsP2



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