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Descriptor English: Buthionine Sulfoximine
Descriptor Spanish: Butionina Sulfoximina
Descriptor butionina sulfoximina
Scope note: Aminoácido sintético que disminuye el glutatión mediante la inhibición irreversible de la gamma-glutamilcisteína sintetasa. La inhibición de esta enzima constituye un paso crítico en la biosíntesis del glutatión. Se ha visto que inhibe la respuesta proliferativa en los linfocitos T humanos y la proliferación de macrófagos. (J Biol Chem 1995;270(33):1945-7)
Descriptor Portuguese: Butionina Sulfoximina
Descriptor French: Buthionine sulfoximine
Entry term(s): Sulfoximine, Buthionine
Tree number(s): D02.886.030.676.620.125
D12.125.166.676.620.125
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D019328
Scope note: A synthetic amino acid that depletes glutathione by irreversibly inhibiting gamma-glutamylcysteine synthetase. Inhibition of this enzyme is a critical step in glutathione biosynthesis. It has been shown to inhibit the proliferative response in human T-lymphocytes and inhibit macrophage activation. (J Biol Chem 1995;270(33):1945-7)
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Antimetabolites
Antimetabolites, Antineoplastic
Enzyme Inhibitors
Radiation-Protective Agents
Radiation-Sensitizing Agents
Registry Number: 5072-26-4
CAS Type 1 Name: Butanoic acid, 2-amino-4-(S-butylsulfonimidoyl)-
Previous Indexing: Methionine Sulfoximine (1979-1996)
Public MeSH Note: 97; BUTHIONINE SULFOXIMINE was indexed under METHIONINE SULFOXIMINE 1979-96
Online Note: use BUTHIONINE SULFOXIMINE (NM) to search BUTHIONINE SULFOXIMINE 1980-96
History Note: 97: was BUTHIONINE SULFOXIMINE (NM) 1979-96
DeCS ID: 33034
Unique ID: D019328
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1997/01/01
Date of Entry: 1996/06/10
Revision Date: 2005/06/30
Buthionine Sulfoximine - Preferred
Concept UI M0028777
Scope note A synthetic amino acid that depletes glutathione by irreversibly inhibiting gamma-glutamylcysteine synthetase. Inhibition of this enzyme is a critical step in glutathione biosynthesis. It has been shown to inhibit the proliferative response in human T-lymphocytes and inhibit macrophage activation. (J Biol Chem 1995;270(33):1945-7)
Preferred term Buthionine Sulfoximine
Entry term(s) Sulfoximine, Buthionine



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