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Descriptor English: Glycyrrhizic Acid
Descriptor Spanish: Ácido Glicirrínico
Descriptor ácido glicirrícico
Entry term(s) glicirricina
Scope note: Agente antiinflamatorio ampliamente utilizado, aislado de la raíz del regaliz. Es metabolizado a ÁCIDO GLICIRRETÍNICO que inhibe las 11-BETA-HIDROXIESTEROIDE DESHIDROGENASAS y otras enzimas implicadas en el metabolismo de los CORTICOSTEROIDES. Por consiguiente, se ha investigado el ácido glicirrícico, que es el componente principal y dulce del regaliz, por su capacidad para causar hipermineralocorticoidismo con retención de sodio y pérdida de potasio, edema, aumento de la presión sanguínea, así como depresión del sistema renina-angiotensina-aldosterona.
Descriptor Portuguese: Ácido Glicirrízico
Descriptor French: Acide glycyrrhizique
Entry term(s): Acid, Glycyrrhizic
Acid, Glycyrrhizinic
Diammonium Glycyrrhizinate
Dipotassium Glycyrrhizinate
Glycyrrhizate, Zinc
Glycyrrhizin
Glycyrrhizinate, Diammonium
Glycyrrhizinate, Dipotassium
Glycyrrhizinic Acid
Zinc Glycyrrhizate
Tree number(s): D02.455.849.919.530.466
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D019695
Scope note: A widely used anti-inflammatory agent isolated from the licorice root. It is metabolized to GLYCYRRHETINIC ACID, which inhibits 11-BETA-HYDROXYSTEROID DEHYDROGENASES and other enzymes involved in the metabolism of CORTICOSTEROIDS. Therefore, glycyrrhizic acid, which is the main and sweet component of licorice, has been investigated for its ability to cause hypermineralocorticoidism with sodium retention and potassium loss, edema, increased blood pressure, as well as depression of the renin-angiotensin-aldosterone system.
Annotation: do not confuse with GLYCYRRHETINIC ACID
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Anti-Inflammatory Agents
Registry Number: 6FO62043WK
CAS Type 1 Name: alpha-D-glucopyranosiduronic acid, (3 beta,20 beta)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-beta-D-glucopyranuronosyl-
Previous Indexing: Glycyrrhetinic Acid (1977-1997)
Glycyrrhiza (1976-1985)
Public MeSH Note: 98; GLYCYRRHIZIC ACID was indexed under GLYCYRRHETINIC ACID 1979-97, GLYCYRRHIZA 1976-79, GLUCOSIDURONATES 1976-79, & ENOXOLONE 1977-79
History Note: 98; see GLYCYRRHIZIC ACID (NM) 1976-97
DeCS ID: 33402
Unique ID: D019695
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1998/01/01
Date of Entry: 1997/06/20
Revision Date: 2013/07/08
Glycyrrhizic Acid - Preferred
Concept UI M0029245
Scope note A widely used anti-inflammatory agent isolated from the licorice root. It is metabolized to GLYCYRRHETINIC ACID, which inhibits 11-BETA-HYDROXYSTEROID DEHYDROGENASES and other enzymes involved in the metabolism of CORTICOSTEROIDS. Therefore, glycyrrhizic acid, which is the main and sweet component of licorice, has been investigated for its ability to cause hypermineralocorticoidism with sodium retention and potassium loss, edema, increased blood pressure, as well as depression of the renin-angiotensin-aldosterone system.
Preferred term Glycyrrhizic Acid
Entry term(s) Acid, Glycyrrhizic
Acid, Glycyrrhizinic
Glycyrrhizin
Glycyrrhizinic Acid
Zinc Glycyrrhizate - Narrower
Concept UI M0029247
Preferred term Zinc Glycyrrhizate
Entry term(s) Glycyrrhizate, Zinc
Diammonium Glycyrrhizinate - Narrower
Concept UI M0503927
Preferred term Diammonium Glycyrrhizinate
Entry term(s) Glycyrrhizinate, Diammonium
Dipotassium Glycyrrhizinate - Narrower
Concept UI M0029246
Preferred term Dipotassium Glycyrrhizinate
Entry term(s) Glycyrrhizinate, Dipotassium



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