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Descriptor English: Thrombospondin 1
Descriptor Spanish: Trombospondina 1
Descriptor trombospondina 1
Entry term(s) TSP-1
Scope note: Glicoproteína de la matriz extracelular de las plaquetas y de diversas células normales y transformadas, tanto de origen mesenquimatoso como epitelial. La trombospondina-1 se cree que desempeñan un papel en la migración y proliferación celular durante la embriogénesis y la reparación de heridas. También, se ha estudiado por su uso como regulador potencial del crecimiento tumoral y de las metástasis.
Descriptor Portuguese: Trombospondina 1
Descriptor French: Thrombospondine-1
Entry term(s): TSP-1
Tree number(s): D09.400.430.890.895.800
D12.776.395.550.895.800
D12.776.543.550.895.800
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D019700
Scope note: An extracellular matrix glycoprotein from platelets and a variety of normal and transformed cells of both mesenchymal and epithelial origin. Thrombospondin-1 is believed to play a role in cell migration and proliferation, during embryogenesis and wound repair. Also, it has been studied for its use as a potential regulator of tumor growth and metastasis.
Annotation: a membrane glycoprotein
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: Membrane Glycoproteins (1993-1997)
Platelet Membrane Glycoproteins (1991-1993)
Public MeSH Note: 98; THROMBOSPONDIN 1 was indexed under MEMBRANE GLYCOPROTEINS 1993-97& PLATELET MEMBRANE GLYCOPROTEINS 1991-93
History Note: 98; see THROMBOSPONDIN (NM) 1991-97
DeCS ID: 33493
Unique ID: D019700
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1998/01/01
Date of Entry: 1997/06/20
Revision Date: 2016/06/28
Thrombospondin 1 - Preferred
Concept UI M0029254
Scope note An extracellular matrix glycoprotein from platelets and a variety of normal and transformed cells of both mesenchymal and epithelial origin. Thrombospondin-1 is believed to play a role in cell migration and proliferation, during embryogenesis and wound repair. Also, it has been studied for its use as a potential regulator of tumor growth and metastasis.
Preferred term Thrombospondin 1
Entry term(s) TSP-1



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