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Descriptor in English: Neuropil Threads
Descriptor in Spanish: Hilos del Neurópilo
Descriptor in Portuguese: Filamentos do Neurópilo
Descriptor in French: Fibres tortueuses
Entry term(s): Neuropil Thread
Tree number(s): A08.637.500.550
A08.675.703.550
A11.284.430.214.190.750.602.620
A11.650.500.550
A11.671.685.550
Scope note: Abnormal structures located chiefly in distal dendrites and, along with NEUROFIBRILLARY TANGLES and SENILE PLAQUES, constitute the three morphological hallmarks of ALZHEIMER DISEASE. Neuropil threads are made up of straight and paired helical filaments which consist of abnormally phosphorylated microtubule-associated tau proteins. It has been suggested that the threads have a major role in the cognitive impairment seen in Alzheimer disease.
Annotation: do not confuse with NEUROPIL, a "felt" of interwoven neuronal components & neuroglia
Allowable Qualifiers: CH chemistry
CL classification
DE drug effects
EN enzymology
GE genetics
IM immunology
ME metabolism
MI microbiology
PA pathology
PH physiology
PS parasitology
RE radiation effects
TR transplantation
UL ultrastructure
VI virology
History Note: 98
DeCS UI: 33622
Descriptor UI: D019600
Date Established: 1998/01/01
Date of Entry: 1997/06/20
Revision Date: 2012/09/27
Neuropil Threads - Preferred
Concept UI M0029099
Scope note Abnormal structures located chiefly in distal dendrites and, along with NEUROFIBRILLARY TANGLES and SENILE PLAQUES, constitute the three morphological hallmarks of ALZHEIMER DISEASE. Neuropil threads are made up of straight and paired helical filaments which consist of abnormally phosphorylated microtubule-associated tau proteins. It has been suggested that the threads have a major role in the cognitive impairment seen in Alzheimer disease.
Preferred term Neuropil Threads
Entry term(s) Neuropil Thread



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