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Descriptor English: Hemidesmosomes
Descriptor Spanish: Hemidesmosomas
Descriptor hemidesmosomas
Scope note: Unión de anclaje de la célula a un sustrato acelular, similar en morfología a mitades de DESMOSOMAS. Son áreas especializadas de la membrana plasmática compuestas por FILAMENTOS INTERMEDIOS que se unen en la superficie citoplasmática a los conectores transmembrana, INTEGRINAS, mediante proteínas de enlace intracelulares, mientras que el dominio extracelular de las integrinas se une a las PROTEÍNAS DE LA MATRIZ EXTRACELULAR.
Descriptor Portuguese: Hemidesmossomos
Descriptor French: Hémidesmosomes
Entry term(s): Hemidesmosome
Tree number(s): A11.284.149.165.165.360
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D022002
Scope note: An anchoring junction of the cell to a non-cellular substrate, similar in morphology to halves of DESMOSOMES. They are composed of specialized areas of the plasma membrane where INTERMEDIATE FILAMENTS bind on the cytoplasmic face to the transmembrane linkers, INTEGRINS, via intracellular attachment proteins, while the extracellular domain of the integrins binds to EXTRACELLULAR MATRIX PROTEINS.
Allowable Qualifiers: CH chemistry
CL classification
DE drug effects
EN enzymology
GE genetics
IM immunology
ME metabolism
MI microbiology
PA pathology
PH physiology
PS parasitology
RE radiation effects
TR transplantation
UL ultrastructure
VI virology
Previous Indexing: Desmosomes (1972-2000)
Public MeSH Note: 2001
History Note: 2001
DeCS ID: 35266
Unique ID: D022002
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2001/01/01
Date of Entry: 2000/06/22
Hemidesmosomes - Preferred
Concept UI M0356381
Scope note An anchoring junction of the cell to a non-cellular substrate, similar in morphology to halves of DESMOSOMES. They are composed of specialized areas of the plasma membrane where INTERMEDIATE FILAMENTS bind on the cytoplasmic face to the transmembrane linkers, INTEGRINS, via intracellular attachment proteins, while the extracellular domain of the integrins binds to EXTRACELLULAR MATRIX PROTEINS.
Preferred term Hemidesmosomes
Entry term(s) Hemidesmosome



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