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Descriptor English: alpha-Mannosidase
Descriptor Spanish: alfa-Manosidasa
Descriptor alfa-manosidasa
Entry term(s) alfa-D-manósido manohidrolasa
alfa-manosidasa lisosómica
Scope note: Enzima que cataliza la HIDRÓLISIS de residuos terminales no reductores de alfa-D-manosa en alfa-D-manósidos. La enzima interviene en la transformación de los N-glucanos recién formados y en la degradación de GLICOPROTEÍNAS maduras. Existen múltiples isoformas de alfa-manosidasa, cada una de las cuales tiene su ubicación celular específica y su pH óptimo. Los defectos de la forma lisosómica de la enzima causan una acumulación de los oligosacáridos ricos en manosa, dando lugar a la ALFA-MANOSIDOSIS.
Descriptor Portuguese: alfa-Manosidase
Descriptor French: alpha-Mannosidase
Entry term(s): LAMAN
Lysosomal alpha Mannosidase
Lysosomal alpha-Mannosidase
Mannohydrolase, alpha-D-Mannoside
Mannosidase B, alpha
Neutral alpha Mannosidase
Neutral alpha-Mannosidase
alpha D Mannosidase
alpha D Mannoside Mannohydrolase
alpha Mannosidase
alpha Mannosidase B
alpha-D-Mannosidase
alpha-D-Mannoside Mannohydrolase
alpha-Mannosidase, Lysosomal
alpha-Mannosidase, Neutral
Tree number(s): D08.811.277.450.625.500
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D043323
Scope note: An enzyme that catalyzes the HYDROLYSIS of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. The enzyme plays a role in the processing of newly formed N-glycans and in degradation of mature GLYCOPROTEINS. There are multiple isoforms of alpha-mannosidase, each having its own specific cellular location and pH optimum. Defects in the lysosomal form of the enzyme results in a buildup of mannoside intermediate metabolites and the disease ALPHA-MANNOSIDOSIS.
Annotation: /DEFIC: consider also ALPHA-MANNOSIDOSIS
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 3.2.1.24
Previous Indexing: Mannosidases (1980-2003)
Public MeSH Note: 2004; ALPHA-MANNOSIDASE was indexed under MANNOSIDASES 1980-2003
History Note: 2004; use ALPHA-MANNOSIDASE (NM) 1980-2003
Related: alpha-Mannosidosis MeSH
DeCS ID: 38163
Unique ID: D043323
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2004/01/01
Date of Entry: 2003/07/09
alpha-Mannosidase - Preferred
Concept UI M0085930
Scope note An enzyme that catalyzes the HYDROLYSIS of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. The enzyme plays a role in the processing of newly formed N-glycans and in degradation of mature GLYCOPROTEINS. There are multiple isoforms of alpha-mannosidase, each having its own specific cellular location and pH optimum. Defects in the lysosomal form of the enzyme results in a buildup of mannoside intermediate metabolites and the disease ALPHA-MANNOSIDOSIS.
Preferred term alpha-Mannosidase
Entry term(s) Mannohydrolase, alpha-D-Mannoside
Neutral alpha Mannosidase
Neutral alpha-Mannosidase
alpha D Mannosidase
alpha D Mannoside Mannohydrolase
alpha Mannosidase
alpha-D-Mannosidase
alpha-D-Mannoside Mannohydrolase
alpha-Mannosidase, Neutral
Lysosomal alpha-Mannosidase - Narrower
Concept UI M0446508
Preferred term Lysosomal alpha-Mannosidase
Entry term(s) LAMAN
Lysosomal alpha Mannosidase
Mannosidase B, alpha
alpha Mannosidase B
alpha-Mannosidase, Lysosomal



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