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Descriptor English: beta-Mannosidase
Descriptor Spanish: beta-Manosidasa
Descriptor beta-manosidasa
Entry term(s) beta-D-manosidasa
Scope note: Enzima que cataliza la hidrólisis de los residuos terminales no reductores de beta-D-manosa en los beta-D-manósidos. La enzima desempeña una función en la degradación lisosómica de los N-glicosilproteína glicanos. En los seres humanos, los defectos en la forma lisosómica de la enzima da lugar a metabolitos intermediarios de manosido y a la enfermedad BETA-MANOSIDOSIS.
Descriptor Portuguese: beta-Manosidase
Descriptor French: beta-Mannosidase
Entry term(s): beta D Mannosidase
beta Mannanase
beta Mannosidase
beta-D-Mannosidase
beta-Mannanase
manA protein (beta-Mannosidase)
Tree number(s): D08.811.277.450.625.750
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D044902
Scope note: An enzyme that catalyzes the hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides. The enzyme plays a role in the lysosomal degradation of the N-glycosylprotein glycans. Defects in the lysosomal form of the enzyme in humans result in a buildup of mannoside intermediate metabolites and the disease BETA-MANNOSIDOSIS.
Annotation: /defic: consider also BETA-MANNOSIDOSIS
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 3.2.1.25
Previous Indexing: Mannosidases (1980-2003)
Public MeSH Note: 2004; BETA-MANNOSIDASE was indexed under MANNOSIDASES 1980-2003
History Note: 2004; use BETA-MANNOSIDASE (NM) 1980-2003
Related: beta-Mannosidosis MeSH
DeCS ID: 38164
Unique ID: D044902
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2004/01/01
Date of Entry: 2003/07/09
beta-Mannosidase - Preferred
Concept UI M0086105
Scope note An enzyme that catalyzes the hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides. The enzyme plays a role in the lysosomal degradation of the N-glycosylprotein glycans. Defects in the lysosomal form of the enzyme in humans result in a buildup of mannoside intermediate metabolites and the disease BETA-MANNOSIDOSIS.
Preferred term beta-Mannosidase
Entry term(s) beta D Mannosidase
beta Mannanase
beta Mannosidase
beta-D-Mannosidase
beta-Mannanase
manA protein (beta-Mannosidase)



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