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Descriptor English: Protease La
Descriptor Spanish: Proteasa La
Descriptor proteasa La
Entry term(s) proteasa Lon
Scope note: Proteasa procariótica dependiente del ATP que interviene en la degradación de muchas proteínas anormales. Es un tetrámero con subunidades de 87 kDa, cada una de las cuales contiene un sitio proteolítico y un sitio de unión al ATP.
Descriptor Portuguese: Protease La
Descriptor French: Protease La
Entry term(s): Endopeptidase La
Lon Protease
Tree number(s): D08.811.277.040.013.500.032.099.750
D08.811.277.040.025.024.032.099.750
D08.811.277.656.149.099.750
D08.811.277.656.300.065.750
D12.776.157.025.750.032.099.750
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D049070
Scope note: A prokaryotic ATP-dependent protease that plays a role in the degradation of many abnormal proteins. It is a tetramer of 87-kDa subunits, each of which contains a proteolytic site and a ATP-binding site.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 3.4.21.53
Previous Indexing: Heat-Shock Proteins (1989-2004)
Peptide Peptidohydrolases (1981-1988)
Serine Endopeptidases (1989-2004)
Public MeSH Note: 2005; PROTEASE LA was indexed under SERINE ENDOPEPTIDASES and HEAT-SHOCK PROTEINS 1989-2004 & under PEPTIDE PEPTIDOHYDROLASES 1981-1988
History Note: 2005(1981)
DeCS ID: 38699
Unique ID: D049070
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2005/01/01
Date of Entry: 2004/07/07
Revision Date: 2017/05/24
Protease La - Preferred
Concept UI M0095049
Scope note A prokaryotic ATP-dependent protease that plays a role in the degradation of many abnormal proteins. It is a tetramer of 87-kDa subunits, each of which contains a proteolytic site and a ATP-binding site.
Preferred term Protease La
Entry term(s) Endopeptidase La
Lon Protease



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