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Descriptor English: Disulfiram
Descriptor Spanish: Disulfiram
Descriptor disulfiram
Entry term(s) disulfuro de tetraetiltiuramo
Scope note: Derivado de carbamato utilizado como disuasorio de la ingesta de alcohol. Es una sustancia relativamente atóxica cuando se administra sola, pero altera acusadamente el metabolismo intermediario del alcohol. Cuando se ingiere alcohol después de la administración de disulfiram, aumentan las concentraciones hemáticas de acetaldehído, que se sigue de rubefacción, vasodilatación sistémica, dificultades respiratorias, náusea, hipotensión y otros síntomas (síndrome acetaldehídico). Actúa inhibidiendo la aldehído deshidrogenasa.
Descriptor Portuguese: Dissulfiram
Descriptor French: Disulfirame
Entry term(s): Alcophobin
Antabus
Antabuse
Anticol
Bis(diethylthiocarbamoyl) Disulfide
Dicupral
Disulfide, Tetraethylthiuram
Esperal
Tetraethylthioperoxydicarbonic Diamide, ((H2N)C(S))2S2
Tetraethylthiuram Disulfide
Teturam
Tree number(s): D02.241.081.251.869.220.250
D02.886.520.150.175
D02.886.706.200.200
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D004221
Scope note: A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Alcohol Deterrents
Acetaldehyde Dehydrogenase Inhibitors
Registry Number: TR3MLJ1UAI
CAS Type 1 Name: Thioperoxydicarbonic diamide (((H2N)C(S))2S2), tetraethyl-
DeCS ID: 4282
Unique ID: D004221
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1966/01/01
Date of Entry: 1999/01/01
Revision Date: 2016/07/05
Disulfiram - Preferred
Concept UI M0006600
Scope note A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.
Preferred term Disulfiram
Entry term(s) Bis(diethylthiocarbamoyl) Disulfide
Disulfide, Tetraethylthiuram
Tetraethylthioperoxydicarbonic Diamide, ((H2N)C(S))2S2
Tetraethylthiuram Disulfide
Antabus - Narrower
Concept UI M0485243
Preferred term Antabus
Antabuse - Narrower
Concept UI M0006601
Preferred term Antabuse
Teturam - Narrower
Concept UI M0006606
Preferred term Teturam
Dicupral - Narrower
Concept UI M0006604
Preferred term Dicupral
Esperal - Narrower
Concept UI M0006605
Preferred term Esperal
Alcophobin - Narrower
Concept UI M0006602
Preferred term Alcophobin
Anticol - Narrower
Concept UI M0006603
Preferred term Anticol



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