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Descriptor English: Encephalomyelitis, Autoimmune, Experimental
Descriptor Spanish: Encefalomielitis Autoinmune Experimental
Descriptor encefalomielitis autoinmune experimental
Entry term(s) encefalomielitis alérgica
encefalomielitis autoinmunitaria experimental
encefalomielitis experimental autoinmune
encefalomielitis experimental autoinmunitaria
Scope note: Modelo animal experimental en relación con las enfermedades desmielinizantes del sistema nervioso central. La inoculación con una emulsión de sustancia blanca combinada con ADYUVANTE DE FREUND, proteína básica de la mielina, o mielina central purificada desencadena una respuesta inmunitaria mediada por las células T dirigida contra la mielina central. Las características anatomopatológicas son similares a las de la ESCLEROSIS MÚLTIPLE, y comprenden focos de inflamación y desmielinización perivascular y periventricular. También se produce desmielinización subpial subyacente a infiltraciones meníngeas, que son también características de la ENCEFALOMIELITIS AGUDA DISEMINADA. La inmunización pasiva con células T de un animal afectado, en un animal normal, induce también esta afección. (Immunol Res 1998;17(1-2):217-27; Raine CS, Textbook of Neuropathology, 2nd ed, p604-5)
Descriptor Portuguese: Encefalomielite Autoimune Experimental
Descriptor French: Encéphalomyélite auto-immune expérimentale
Entry term(s): Allergic Encephalomyelitis
Allergic Encephalomyelitis, Experimental
Autoimmune Encephalomyelitis, Experimental
Autoimmune Experimental Encephalomyelitis
Encephalomyelitis, Allergic
Encephalomyelitis, Autoimmune Experimental
Encephalomyelitis, Experimental Allergic
Encephalomyelitis, Experimental Autoimmune
Experimental Allergic Encephalomyelitides
Experimental Allergic Encephalomyelitis
Experimental Autoimmune Encephalomyelitis
Experimental Encephalomyelitis, Autoimmune
Tree number(s): C10.114.703.300
C10.228.140.695.562.250
C10.314.350.250
C20.111.258.625.300
E05.598.500.500.500
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D004681
Scope note: An experimental animal model for central nervous system demyelinating disease. Inoculation with a white matter emulsion combined with FREUND'S ADJUVANT, myelin basic protein, or purified central myelin triggers a T cell-mediated immune response directed towards central myelin. The pathologic features are similar to MULTIPLE SCLEROSIS, including perivascular and periventricular foci of inflammation and demyelination. Subpial demyelination underlying meningeal infiltrations also occurs, which is also a feature of ENCEPHALOMYELITIS, ACUTE DISSEMINATED. Passive immunization with T-cells from an afflicted animal to a normal animal also induces this condition. (From Immunol Res 1998;17(1-2):217-27; Raine CS, Textbook of Neuropathology, 2nd ed, p604-5)
Annotation: coordinate with specific demyelinating disease if pertinent
Allowable Qualifiers: BL blood
CF cerebrospinal fluid
CI chemically induced
CL classification
CO complications
DG diagnostic imaging
DH diet therapy
DI diagnosis
DT drug therapy
EC economics
EH ethnology
EM embryology
EN enzymology
EP epidemiology
ET etiology
GE genetics
HI history
IM immunology
ME metabolism
MI microbiology
MO mortality
NU nursing
PA pathology
PC prevention & control
PP physiopathology
PS parasitology
PX psychology
RH rehabilitation
RT radiotherapy
SU surgery
TH therapy
UR urine
VE veterinary
VI virology
Public MeSH Note: 2005; see ENCEPHALOMYELITIS, EXPERIMENTAL AUTOIMMUNE 2000-2004, see ENCEPHALOMYELITIS, ALLERGIC 1964-1999
History Note: 2005 (1964)
Entry Version: ENCEPH AUTOIMMUNE EXPER
DeCS ID: 4760
Unique ID: D004681
NLM Classification: WL 351
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1966/01/01
Date of Entry: 1999/01/01
Revision Date: 2022/04/13
Encephalomyelitis, Autoimmune, Experimental - Preferred
Concept UI M0007370
Scope note An experimental animal model for central nervous system demyelinating disease. Inoculation with a white matter emulsion combined with FREUND'S ADJUVANT, myelin basic protein, or purified central myelin triggers a T cell-mediated immune response directed towards central myelin. The pathologic features are similar to MULTIPLE SCLEROSIS, including perivascular and periventricular foci of inflammation and demyelination. Subpial demyelination underlying meningeal infiltrations also occurs, which is also a feature of ENCEPHALOMYELITIS, ACUTE DISSEMINATED. Passive immunization with T-cells from an afflicted animal to a normal animal also induces this condition. (From Immunol Res 1998;17(1-2):217-27; Raine CS, Textbook of Neuropathology, 2nd ed, p604-5)
Preferred term Encephalomyelitis, Autoimmune, Experimental
Entry term(s) Allergic Encephalomyelitis, Experimental
Autoimmune Encephalomyelitis, Experimental
Autoimmune Experimental Encephalomyelitis
Encephalomyelitis, Autoimmune Experimental
Encephalomyelitis, Experimental Allergic
Encephalomyelitis, Experimental Autoimmune
Experimental Allergic Encephalomyelitides
Experimental Allergic Encephalomyelitis
Experimental Autoimmune Encephalomyelitis
Experimental Encephalomyelitis, Autoimmune
Encephalomyelitis, Allergic - Related but not broader or narrower
Concept UI M000755308
Preferred term Encephalomyelitis, Allergic
Entry term(s) Allergic Encephalomyelitis



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