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Descriptor English: Keratin-12
Descriptor Spanish: Queratina-12
Descriptor queratina 12
Entry term(s) queratina-12
Scope note: Queratina de tipo I que se encuentra asociada con la QUERATINA 3 en la CÓRNEA, y a la que se considera un marcador de diferenciación epitelial de tipo corneal. Las mutaciones de los genes de la queratina 12 se han asociado a la DISTROFIA EPITELIAL CORNEAL DE MEESMANN.
Descriptor Portuguese: Queratina-12
Descriptor French: Kératine-12
Entry term(s): Cytokeratin 12
Cytokeratin-12
Keratin 12
Tree number(s): D05.750.078.593.450.300.200
D12.776.220.475.450.300.200
D12.776.860.607.300.200
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D053551
Scope note: A type I keratin that is found associated with the KERATIN-3 in the CORNEA and is regarded as a marker for corneal-type epithelial differentiation. Mutations in the gene for keratin-12 have been associated with MEESMANN CORNEAL EPITHELIAL DYSTROPHY.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Entry Combination: deficiency:Corneal Dystrophy, Juvenile Epithelial of Meesmann
Previous Indexing: Keratin (1992-2006)
Public MeSH Note: 2007; KERATIN-12 was indexed under KERATINS 2003-2006
History Note: 2007(2003)
DeCS ID: 52185
Unique ID: D053551
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2007/01/01
Date of Entry: 2006/07/05
Keratin-12 - Preferred
Concept UI M0449766
Scope note A type I keratin that is found associated with the KERATIN-3 in the CORNEA and is regarded as a marker for corneal-type epithelial differentiation. Mutations in the gene for keratin-12 have been associated with MEESMANN CORNEAL EPITHELIAL DYSTROPHY.
Preferred term Keratin-12
Entry term(s) Cytokeratin 12
Cytokeratin-12
Keratin 12



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