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Descriptor English: Amyloid Precursor Protein Secretases
Descriptor Spanish: Secretasas de la Proteína Precursora del Amiloide
Descriptor secretasas de la proteína precursora del amiloide
Entry term(s) secretasas del precursor del amiloide
Scope note: Endopeptidasas específicas de la PROTEÍNA PRECURSORA DEL AMILOIDE. Se han identificado tres subtipos de secretasa, denominadas alfa, beta y gamma en función de la región de la proteína precursora del amiloide que escinden.
Descriptor Portuguese: Secretases da Proteína Precursora do Amiloide
Descriptor French: Amyloid precursor protein secretases
Entry term(s): APP Secretase
Amyloid Precursor Protein Secretase
Secretase
Secretase, APP
Secretases
alpha Secretase
alpha-Secretase
beta Secretase
beta-Secretase
gamma Secretase
gamma-Secretase
Tree number(s): D08.811.277.656.300.032
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D053829
Scope note: Endopeptidases that are specific for AMYLOID PROTEIN PRECURSOR. Three secretase subtypes referred to as alpha, beta, and gamma have been identified based upon the region of amyloid protein precursor they cleave.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 3.4.-
Public MeSH Note: 2007; SECRETASE was indexed under ENDOPEPTIDASES 1992-2006
History Note: 2007(1992)
DeCS ID: 52219
Unique ID: D053829
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2007/01/01
Date of Entry: 2006/07/05
Amyloid Precursor Protein Secretases - Preferred
Concept UI M0205216
Scope note Endopeptidases that are specific for AMYLOID PROTEIN PRECURSOR. Three secretase subtypes referred to as alpha, beta, and gamma have been identified based upon the region of amyloid protein precursor they cleave.
Preferred term Amyloid Precursor Protein Secretases
Entry term(s) APP Secretase
Amyloid Precursor Protein Secretase
Secretase
Secretase, APP
Secretases
beta-Secretase - Narrower
Concept UI M0470165
Preferred term beta-Secretase
Entry term(s) beta Secretase
gamma-Secretase - Narrower
Concept UI M0205215
Preferred term gamma-Secretase
Entry term(s) gamma Secretase
alpha-Secretase - Narrower
Concept UI M0205212
Preferred term alpha-Secretase
Entry term(s) alpha Secretase



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