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Descriptor in English: Osteoprotegerin
Descriptor in Spanish: Osteoprotegerina
Descriptor in Portuguese: Osteoprotegerina
Descriptor in French: Ostéoprotégérine
Entry term(s): FDCR 1 Protein
FDCR-1 Protein
Follicular Dendritic Cell Derived Receptor 1
Follicular Dendritic Cell-Derived Receptor-1
OCIF Protein
Osteoclastogenesis Inhibitory Factor
Receptors, Tumor Necrosis Factor, Member 11b
Tumor Necrosis Factor Receptor 11b
Tumor Necrosis Factor Receptor Superfamily, Member 11b
Tree number(s): D12.776.543.750.705.852.760.949.249
Scope note: A secreted member of the TNF receptor superfamily that negatively regulates osteoclastogenesis. It is a soluble decoy receptor of RANK LIGAND that inhibits both CELL DIFFERENTIATION and function of OSTEOCLASTS by inhibiting the interaction between RANK LIGAND and RECEPTOR ACTIVATOR OF NUCLEAR FACTOR-KAPPA B.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
History Note: 2007(1997)
DeCS UI: 52396
Descriptor UI: D053244
Date Established: 2007/01/01
Date of Entry: 2006/07/05
Osteoprotegerin - Preferred
Concept UI M0275318
Scope note A secreted member of the TNF receptor superfamily that negatively regulates osteoclastogenesis. It is a soluble decoy receptor of RANK LIGAND that inhibits both CELL DIFFERENTIATION and function of OSTEOCLASTS by inhibiting the interaction between RANK LIGAND and RECEPTOR ACTIVATOR OF NUCLEAR FACTOR-KAPPA B.
Preferred term Osteoprotegerin
Entry term(s) FDCR 1 Protein
FDCR-1 Protein
Follicular Dendritic Cell Derived Receptor 1
Follicular Dendritic Cell-Derived Receptor-1
OCIF Protein
Osteoclastogenesis Inhibitory Factor
Receptors, Tumor Necrosis Factor, Member 11b
Tumor Necrosis Factor Receptor 11b
Tumor Necrosis Factor Receptor Superfamily, Member 11b



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