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Descriptor English: Lissencephaly
Descriptor Spanish: Lisencefalia
Descriptor Portuguese: Lisencefalia
Descriptor French: Lissencéphalie
Entry term(s): Agyria
Agyrias
Broad Gyri of Cerebrum
Large Gyri of Cerebrum
Lissencephalia
Lissencephalies
Macrogyria
Macrogyrias
Pachygyria
Pachygyrias
Tree number(s): C10.500.507.450.499
C16.131.666.507.450.499
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D054082
Scope note: A smooth brain malformation of the CEREBRAL CORTEX resulting from the abnormal location of developing neurons during corticogenesis. It is characterized by an absence of normal convoluted indentations on the surface of the brain (agyria), or fewer and shallower indentations (pachygryia). There is a reduced number of cortical layers, typically 4 instead of 6, resulting in a thickened cortex, and reduced cerebral white matter that is a reversal of the normal ratio of cerebral white matter to cortex.
Annotation: note specifics; MICROLISSENCEPHALY see MICROCEPHALY is also available
Allowable Qualifiers: BL blood
CF cerebrospinal fluid
CI chemically induced
CL classification
CO complications
DG diagnostic imaging
DH diet therapy
DI diagnosis
DT drug therapy
EC economics
EH ethnology
EM embryology
EN enzymology
EP epidemiology
ET etiology
GE genetics
HI history
IM immunology
ME metabolism
MI microbiology
MO mortality
NU nursing
PA pathology
PC prevention & control
PP physiopathology
PS parasitology
PX psychology
RH rehabilitation
RT radiotherapy
SU surgery
TH therapy
UR urine
VE veterinary
VI virology
Public MeSH Note: 2008
History Note: 2008
DeCS ID: 52594
Unique ID: D054082
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2008/01/01
Date of Entry: 2007/07/09
Revision Date: 2016/02/26
Lissencephaly - Preferred
Concept UI M0501372
Scope note A smooth brain malformation of the CEREBRAL CORTEX resulting from the abnormal location of developing neurons during corticogenesis. It is characterized by an absence of normal convoluted indentations on the surface of the brain (agyria), or fewer and shallower indentations (pachygryia). There is a reduced number of cortical layers, typically 4 instead of 6, resulting in a thickened cortex, and reduced cerebral white matter that is a reversal of the normal ratio of cerebral white matter to cortex.
Preferred term Lissencephaly
Entry term(s) Lissencephalia
Lissencephalies
Agyria - Related but not broader or narrower
Concept UI M0501373
Preferred term Agyria
Entry term(s) Agyrias
Pachygyria - Related but not broader or narrower
Concept UI M0501374
Preferred term Pachygyria
Entry term(s) Broad Gyri of Cerebrum
Large Gyri of Cerebrum
Macrogyria
Macrogyrias
Pachygyrias



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