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Descriptor English: Connective Tissue Growth Factor
Descriptor Spanish: Factor de Crecimiento del Tejido Conjuntivo
Descriptor factor de crecimiento del tejido conjuntivo
Scope note: Miembro de la familia de proteínas CCN que regulan diversas funciones extracelulares, incluidas la ADHERENCIA CELULAR, la MIGRACIÓN CELULAR y la síntesis de la MATRIZ EXTRACELULAR. Se encuentra en los CONDROCITOS hipertróficos donde puede desempeñar un papel fundamental en la CONDROGÉNESIS y en la osificación endocondral.
Descriptor Portuguese: Fator de Crescimento do Tecido Conjuntivo
Descriptor French: Facteur de croissance du tissu conjonctif
Entry term(s): CCN2 Protein
Hypertrophic Chondrocyte Specific Protein 24
Hypertrophic Chondrocyte-Specific Protein 24
IGF Binding Protein Related Protein 2
IGF-Binding Protein-Related Protein-2
IGFBP-8
IGFBP-rP2
Insulin Like Growth Factor Binding Protein 8
Insulin-Like Growth Factor Binding Protein 8
Tree number(s): D12.644.276.200.100
D12.776.467.200.100
D12.776.860.300.200.100
D23.529.237.100
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D055513
Scope note: A CCN protein family member that regulates a variety of extracellular functions including CELL ADHESION; CELL MIGRATION; and EXTRACELLULAR MATRIX synthesis. It is found in hypertrophic CHONDROCYTES where it may play a role in CHONDROGENESIS and endochondral ossification.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: 139568-91-5
Public MeSH Note: 2009; CONNECTIVE TISSUE GROWTH FACTOR was indexed under IMMEDIATE EARLY PROTEINS, & INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS 2003-2008, & under GROWTH SUBSTANCES 1991-2002
History Note: 2009(1991)
DeCS ID: 53124
Unique ID: D055513
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2009/01/01
Date of Entry: 2008/07/08
Connective Tissue Growth Factor - Preferred
Concept UI M0192848
Scope note A CCN protein family member that regulates a variety of extracellular functions including CELL ADHESION; CELL MIGRATION; and EXTRACELLULAR MATRIX synthesis. It is found in hypertrophic CHONDROCYTES where it may play a role in CHONDROGENESIS and endochondral ossification.
Preferred term Connective Tissue Growth Factor
Entry term(s) CCN2 Protein
Hypertrophic Chondrocyte Specific Protein 24
Hypertrophic Chondrocyte-Specific Protein 24
IGF Binding Protein Related Protein 2
IGF-Binding Protein-Related Protein-2
IGFBP-8
IGFBP-rP2
Insulin Like Growth Factor Binding Protein 8
Insulin-Like Growth Factor Binding Protein 8



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