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Descriptor English: Pemetrexed
Descriptor Spanish: Pemetrexed
Descriptor Portuguese: Pemetrexede
Descriptor French: Pémétrexed
Entry term(s): 231,514, LY
231514, LY
Alimta
Disodium, Pemetrexed
LY 231,514
LY 231514
LY-231,514
LY-231514
LY231514
MTA
N-(4-(2-(2-amino-3,4-dihydro-4-oxo-7H-pyrrolo(2,3-d)pyrimdin-5-yl)ethyl)benzoyl)glutamic acid
Pemetrexed Disodium
Tree number(s): D03.633.100.759.758.399.454.650
D12.125.067.625.525
D12.125.119.409.525
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000068437
Scope note: A guanine-derived ANTINEOPLASTIC AGENT that functions as a NUCLEIC ACID SYNTHESIS INHIBITOR through its binding to, and inhibition of, THYMIDYLATE SYNTHASE.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Antineoplastic Agents
Enzyme Inhibitors
Folic Acid Antagonists
Nucleic Acid Synthesis Inhibitors
Registry Number: 04Q9AIZ7NO
CAS Type 1 Name: L-Glutamic acid, N-(4-(2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo(2,3-d)pyrimidin-5-yl)ethyl)benzoyl)-
Public MeSH Note: 2016; PEMETREXED was indexed under GLUTAMATES 1994-2015, and under GUANINE 1994-2015
History Note: 2016 (1994)
DeCS ID: 55935
Unique ID: D000068437
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2016/01/01
Date of Entry: 2015/07/01
Revision Date: 2016/05/31
Pemetrexed - Preferred
Concept UI M0227083
Scope note A guanine-derived ANTINEOPLASTIC AGENT that functions as a NUCLEIC ACID SYNTHESIS INHIBITOR through its binding to, and inhibition of, THYMIDYLATE SYNTHASE.
Preferred term Pemetrexed
Entry term(s) MTA
N-(4-(2-(2-amino-3,4-dihydro-4-oxo-7H-pyrrolo(2,3-d)pyrimdin-5-yl)ethyl)benzoyl)glutamic acid
Pemetrexed Disodium - Narrower
Concept UI M000603406
Preferred term Pemetrexed Disodium
Entry term(s) Disodium, Pemetrexed
LY 231514 - Narrower
Concept UI M0227084
Preferred term LY 231514
Entry term(s) 231,514, LY
231514, LY
LY 231,514
LY-231,514
LY-231514
LY231514
Alimta - Narrower
Concept UI M0407271
Preferred term Alimta



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