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Descriptor English: Alarmins
Descriptor Spanish: Alarminas
Descriptor alarminas
Entry term(s) alarmina
moléculas de patrones moleculares asociadas a daño
moléculas de patrones moleculares asociadas a peligro
Scope note: Grupo estructuralmente diverso de moléculas endógenas multifuncionales, que tienen funciones fisiológicas dentro de la célula, pero que cuando son liberadas por células muertas o sometidas a estrés, o por ciertas células inmunitarias, activan la INMUNIDAD INNATA. La liberación incontrolada y excesiva de alarminas puede contribuir a la INFLAMACIÓN, la CARCINOGÉNESIS y las METÁSTASIS. Las alarminas también son cruciales para la homeostasis del corazón y del tejido nervioso.
Descriptor Portuguese: Alarminas
Descriptor French: Alarmines
Entry term(s): Alarmin
Alarmin Proteins
Damage Associated Molecular Pattern Molecules
Damage-Associated Molecular Pattern Molecules
Danger Associated Molecular Pattern Molecules
Danger-Associated Molecular Pattern Molecules
Tree number(s): D23.035
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000067531
Scope note: A structurally diverse group of endogenous molecules that are multifunctional, having physiological functions inside the cell, but when released from dying cells or from cells under stress or certain immune cells, they function to activate INNATE IMMUNITY. Uncontrolled and excessive release of alarmins may contribute to INFLAMMATION; CARCINOGENESIS, and NEOPLASM METASTASIS. Alarmins are also critical for heart and nerve tissue homeostasis.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: HMGB1 Protein (2004-2015)
Public MeSH Note: 2016
History Note: 2016
DeCS ID: 55964
Unique ID: D000067531
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2016/01/01
Date of Entry: 2015/07/01
Revision Date: 2016/06/30
Alarmins - Preferred
Concept UI M000599994
Scope note A structurally diverse group of endogenous molecules that are multifunctional, having physiological functions inside the cell, but when released from dying cells or from cells under stress or certain immune cells, they function to activate INNATE IMMUNITY. Uncontrolled and excessive release of alarmins may contribute to INFLAMMATION; CARCINOGENESIS, and NEOPLASM METASTASIS. Alarmins are also critical for heart and nerve tissue homeostasis.
Preferred term Alarmins
Entry term(s) Alarmin
Alarmin Proteins
Damage Associated Molecular Pattern Molecules
Damage-Associated Molecular Pattern Molecules
Danger Associated Molecular Pattern Molecules
Danger-Associated Molecular Pattern Molecules



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