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Descriptor in English: Alarmins
Descriptor in Spanish: Alarminas
Descriptor in Portuguese: Alarminas
Descriptor in French: Alarmines
Entry term(s): Alarmin
Alarmin Proteins
Damage Associated Molecular Pattern Molecules
Damage-Associated Molecular Pattern Molecules
Danger Associated Molecular Pattern Molecules
Danger-Associated Molecular Pattern Molecules
Tree number(s): D23.035
Scope note: A structurally diverse group of endogenous molecules that are multifunctional, having physiological functions inside the cell, but when released from dying cells or from cells under stress or certain immune cells, they function to activate INNATE IMMUNITY. Uncontrolled and excessive release of alarmins may contribute to INFLAMMATION; CARCINOGENESIS, and NEOPLASM METASTASIS. Alarmins are also critical for heart and nerve tissue homeostasis.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
History Note: 2016
DeCS UI: 55964
Descriptor UI: D000067531
Date Established: 2016/01/01
Date of Entry: 2015/07/01
Revision Date: 2016/06/30
Alarmins - Preferred
Concept UI M000599994
Scope note A structurally diverse group of endogenous molecules that are multifunctional, having physiological functions inside the cell, but when released from dying cells or from cells under stress or certain immune cells, they function to activate INNATE IMMUNITY. Uncontrolled and excessive release of alarmins may contribute to INFLAMMATION; CARCINOGENESIS, and NEOPLASM METASTASIS. Alarmins are also critical for heart and nerve tissue homeostasis.
Preferred term Alarmins
Entry term(s) Alarmin
Alarmin Proteins
Damage Associated Molecular Pattern Molecules
Damage-Associated Molecular Pattern Molecules
Danger Associated Molecular Pattern Molecules
Danger-Associated Molecular Pattern Molecules



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