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Descriptor English: Oxaliplatin
Descriptor Spanish: Oxaliplatino
Descriptor oxaliplatino
Entry term(s) 1,2-diaminociclohexano(trans-1)oxalatoplatino(II)
ACT 078
ACT-078
ACT078
L-OHP Cpd
cis-oxalato-(trans-l)-1,2-diaminociclohexano-platino(II)
eloxatin
etanodioato de platino(2+) (1R,2R)-1,2-ciclohexanodiamina (1:1:1)
isómero (SP-4-2-(1R-trans)) del oxaliplatino
isómero (SP-4-2-(1S-trans)) del oxaliplatino
isómero (SP-4-3-(cis)) del oxaliplatino
oxalato de platino(II)-1,2-ciclohexanodiamina
oxalato-(1,2-ciclohexanodiamina)platino II
oxalato-1,2 diaminociclohexano de platino
oxalato-1,2-diaminociclohexano de platino
oxaliplatina
Scope note: Complejo de organoplatino en el que el átomo de platino forma un complejo con 1,2-diaminociclohexano y con un ligando oxalato que es desplazado para generar derivados de oxaliplatino activos. Estos derivados forman entrecruzamientos intercatenarios e intracatenarios en el ADN que inhiben la replicación y la transcripción del ADN. El oxaliplatino es un antineoplásico que a menudo se administra con FLUOROURACILO y ÁCIDO FOLÍNICO en el tratamiento de las NEOPLASIAS COLORRECTALES metastásicas.
Descriptor Portuguese: Oxaliplatina
Descriptor French: Oxaliplatine
Entry term(s): 1,2 Diaminocyclohexane Platinum Oxalate
1,2-Diaminocyclohexane Platinum Oxalate
1,2-Diamminocyclohexane(trans-1)oxolatoplatinum(II)
ACT 078
ACT-078
ACT078
Cis-oxalato-(trans-l)-1,2-diaminocyclohexane-platinum(II)
Eloxatin
Eloxatine
L-OHP Cpd
Oxalato-(1,2-cyclohexanediamine)platinum II
Oxaliplatin, (SP-4-2-(1R-trans))-isomer
Oxaliplatin, (SP-4-2-(1S-trans))-isomer
Oxaliplatin, (SP-4-3-(cis))-isomer
Oxaliplatine
Platinum(2+) ethanedioate (1R,2R)-1,2-cyclohexanediamine (1:1:1)
Platinum(II)-1,2-cyclohexanediamine Oxalate
Tree number(s): D02.257.750
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000077150
Scope note: An organoplatinum complex in which the platinum atom is complexed with 1,2-diaminocyclohexane, and with an oxalate ligand which is displaced to yield active oxaliplatin derivatives. These derivatives form inter- and intra-strand DNA crosslinks that inhibit DNA replication and transcription. Oxaliplatin is an antineoplastic agent that is often administered with FLUOROURACIL and FOLINIC ACID in the treatment of metastatic COLORECTAL NEOPLASMS.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Antineoplastic Agents
Registry Number: 04ZR38536J
CAS Type 1 Name: Platinum(2+) ethanedioate (1R,2R)-1,2-cyclohexanediamine (1:1:1)
Public MeSH Note: 2019; OXALIPLATIN was indexed under ORGANOPLATINUM COMPOUNDS 1981-2018
History Note: 2019 (1981)
DeCS ID: 57521
Unique ID: D000077150
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2019/01/01
Date of Entry: 2018/07/09
Revision Date: 2019/07/05
Oxaliplatin - Preferred
Concept UI M0095550
Scope note An organoplatinum complex in which the platinum atom is complexed with 1,2-diaminocyclohexane, and with an oxalate ligand which is displaced to yield active oxaliplatin derivatives. These derivatives form inter- and intra-strand DNA crosslinks that inhibit DNA replication and transcription. Oxaliplatin is an antineoplastic agent that is often administered with FLUOROURACIL and FOLINIC ACID in the treatment of metastatic COLORECTAL NEOPLASMS.
Preferred term Oxaliplatin
Entry term(s) 1,2 Diaminocyclohexane Platinum Oxalate
1,2-Diaminocyclohexane Platinum Oxalate
1,2-Diamminocyclohexane(trans-1)oxolatoplatinum(II)
L-OHP Cpd
Oxalato-(1,2-cyclohexanediamine)platinum II
Oxaliplatin, (SP-4-2-(1R-trans))-isomer
Oxaliplatine
Platinum(2+) ethanedioate (1R,2R)-1,2-cyclohexanediamine (1:1:1)
Platinum(II)-1,2-cyclohexanediamine Oxalate
Eloxatine - Narrower
Concept UI M0433269
Preferred term Eloxatine
Eloxatin - Narrower
Concept UI M000639457
Preferred term Eloxatin
Oxaliplatin, (SP-4-3-(cis))-isomer - Narrower
Concept UI M0318698
Preferred term Oxaliplatin, (SP-4-3-(cis))-isomer
ACT 078 - Narrower
Concept UI M0095545
Preferred term ACT 078
Entry term(s) ACT-078
ACT078
Cis-oxalato-(trans-l)-1,2-diaminocyclohexane-platinum(II) - Narrower
Concept UI M0095547
Preferred term Cis-oxalato-(trans-l)-1,2-diaminocyclohexane-platinum(II)
Oxaliplatin, (SP-4-2-(1S-trans))-isomer - Narrower
Concept UI M0318696
Preferred term Oxaliplatin, (SP-4-2-(1S-trans))-isomer



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