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Descriptor English: Pregnane X Receptor
Descriptor Spanish: Receptor X de Pregnano
Descriptor receptor X de pregnano
Entry term(s) NR1I2
miembro 2 del grupo I de la subfamilia 1 de receptores nucleares
receptor SXR
receptor X de esteroides
receptor de esteroides y xenobióticos
Scope note: Receptor esteroideo que se une a diversos compuestos endógenos y XENOBIÓTICOS y que es activado por ellos. Se une al elemento de respuesta en los promotores de genes que codifican las proteínas del CITOCROMO P-450, miembro CYP3A4, y del TRANSPORTADOR DE CASETES DE UNIÓN AL ATP, SUBFAMILIA B, MIEMBRO 1, y activa también la transcripción de diversos genes que intervienen en el metabolismo y en la secreción de fármacos, compuestos endógenos y xenobióticos potencialmente nocivos. Es activado por el antibiótico RIFAMPICINA y por diversos metabolitos vegetales, tales como la hiperforina, el gugulípido, la colupulona y las ISOFLAVONAS.
Descriptor Portuguese: Receptor de Pregnano X
Descriptor French: Récepteur du prégnane X
Entry term(s): NR1I2
Nuclear Receptor Subfamily 1, Group I, Member 2
SXR Receptor
Steroid X Receptor
Steroid and Xenobiotic Receptor
Tree number(s): D12.776.826.750.075
D12.776.930.778.175
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000077297
Scope note: Steroid receptor that binds and is activated by variety of endogenous compounds and XENOBIOTICS. It binds the response element in promoters of genes that encode CYTOCHROME P450 3A4 and ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B, MEMBER 1 proteins, and also activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs, and endogenous compounds. It is activated by the antibiotic RIFAMPICIN and various plant metabolites, such as hyperforin, guggulipid, colupulone, and ISOFLAVONES.
Allowable Qualifiers: AD administration & dosage
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CH chemistry
CL classification
DE drug effects
DF deficiency
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PH physiology
RE radiation effects
TU therapeutic use
UL ultrastructure
Public MeSH Note: 2019; PREGNANE X RECEPTOR was indexed under RECEPTORS, STEROID 2007-2018; and under RECEPTORS, CYTOPLASMIC AND NUCLEAR 1998-2006
History Note: 2019 (1998)
DeCS ID: 57597
Unique ID: D000077297
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2019/01/01
Date of Entry: 2018/07/09
Revision Date: 2018/02/28
Pregnane X Receptor - Preferred
Concept UI M0287170
Scope note Steroid receptor that binds and is activated by variety of endogenous compounds and XENOBIOTICS. It binds the response element in promoters of genes that encode CYTOCHROME P450 3A4 and ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B, MEMBER 1 proteins, and also activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs, and endogenous compounds. It is activated by the antibiotic RIFAMPICIN and various plant metabolites, such as hyperforin, guggulipid, colupulone, and ISOFLAVONES.
Preferred term Pregnane X Receptor
Entry term(s) NR1I2
Nuclear Receptor Subfamily 1, Group I, Member 2
SXR Receptor
Steroid X Receptor
Steroid and Xenobiotic Receptor



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