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Descriptor English: Simendan
Descriptor Spanish: Simendán
Descriptor simendán
Entry term(s) ((4-(1,4,5,6-tetrahidro-4-metil-6-oxo-3-piridazinil)fenil)hidrazono)propanedinitrilo
Dextrosimendan
OR 1259
OR 1855
OR-1259
OR-1855
Simadax
levosimendan
Scope note: Derivado de hidrazona y piridazina; la forma levógira es un inhibidor de la fosfodiesterasa III, sensibilizante al calcio e inotrópico que se usa en el tratamiento de la INSUFICIENCIA CARDÍACA.
Descriptor Portuguese: Simendana
Descriptor French: Simendan
Entry term(s): ((4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl)hydrazono)propanedinitrile
Dextrosimendan
Levosimendan
OR 1259
OR 1855
OR-1259
OR-1855
Simadax
Tree number(s): D02.442.288.610
D03.383.710.802
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000077464
Scope note: A hydrazone and pyridazine derivative; the levo-form is a phosphodiesterase III inhibitor, calcium-sensitizing agent, and inotropic agent that is used in the treatment of HEART FAILURE.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Cardiotonic Agents
Vasodilator Agents
Phosphodiesterase 3 Inhibitors
Registry Number: 349552KRHK
CAS Type 1 Name: Propanedinitrile, 2-(2-(4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl)hydrazinylidene)-
Public MeSH Note: 2019; SIMENDAN was indexed under HYDRAZONES and PYRIDAZINES 1992-2018
History Note: 2019 (1992)
DeCS ID: 57652
Unique ID: D000077464
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2019/01/01
Date of Entry: 2018/07/09
Revision Date: 2018/07/03
Simendan - Preferred
Concept UI M0206272
Scope note A hydrazone and pyridazine derivative; the levo-form is a phosphodiesterase III inhibitor, calcium-sensitizing agent, and inotropic agent that is used in the treatment of HEART FAILURE.
Preferred term Simendan
Entry term(s) ((4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl)hydrazono)propanedinitrile
Simadax - Narrower
Concept UI M0514419
Preferred term Simadax
Dextrosimendan - Narrower
Concept UI M0206271
Preferred term Dextrosimendan
OR 1259 - Narrower
Concept UI M0206269
Preferred term OR 1259
Entry term(s) OR-1259
Levosimendan - Narrower
Concept UI M0206268
Preferred term Levosimendan
OR-1855 - Narrower
Concept UI M0351148
Preferred term OR-1855
Entry term(s) OR 1855



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