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Descriptor English: Tiagabine
Descriptor Spanish: Tiagabina
Descriptor tiagabina
Entry term(s) Gabitril
NO 328
NO 329
NO-328
NO-329
hidrocloruro de tiagabina
hidrocloruro del ácido (R)-(4,4-bis(3-metil-2-tienil)-3-butenil)-3-piperidincarboxílico
isómero (S) de la tiagabina
ácido N-(4,4-di(3-metiltien-2-il)but-3-enil)nipecótico
Scope note: Derivado del ácido nipecótico que actúa como inhibidor de la captación de GABA y como anticonvulsivo. Se usa en el tratamiento de la EPILEPSIA, para las EPILEPSIAS PARCIALES resistentes al tratamiento.
Descriptor Portuguese: Tiagabina
Descriptor French: Tiagabine
Entry term(s): (R)-(4,4-bis(3-Methyl-2-thienyl)-3-butenyl)-3-piperidinecarboxylic acid, Hydrochloride
Gabitril
N-(4,4-di(3-Methylthien-2-yl)but-3-enyl)nipecotic acid
NO 328
NO 329
NO-328
NO-329
Tiagabine Hydrochloride
Tiagabine, (S)-isomer
Tree number(s): D03.066.566.500
D03.383.621.566.500
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000078308
Scope note: A nipecotic acid derivative that acts as a GABA uptake inhibitor and anticonvulsant agent. It is used in the treatment of EPILEPSY, for refractory PARTIAL SEIZURES.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Anticonvulsants
GABA Uptake Inhibitors
Registry Number: Z80I64HMNP
CAS Type 1 Name: 3-Piperidinecarboxylic acid, 1-(4,4-bis(3-methyl-2-thienyl)-3-buten-1-yl)-, (3R)-
Public MeSH Note: 2019; TIAGABINE was indexed under NIPECOTIC ACIDS 1989-2018
History Note: 2019 (1989)
DeCS ID: 57799
Unique ID: D000078308
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2019/01/01
Date of Entry: 2018/07/09
Revision Date: 2018/05/21
Tiagabine - Preferred
Concept UI M0164774
Scope note A nipecotic acid derivative that acts as a GABA uptake inhibitor and anticonvulsant agent. It is used in the treatment of EPILEPSY, for refractory PARTIAL SEIZURES.
Preferred term Tiagabine
Entry term(s) N-(4,4-di(3-Methylthien-2-yl)but-3-enyl)nipecotic acid
Gabitril - Narrower
Concept UI M0386284
Preferred term Gabitril
NO 329 - Narrower
Concept UI M0164771
Preferred term NO 329
Entry term(s) NO-329
Tiagabine Hydrochloride - Narrower
Concept UI M0164768
Preferred term Tiagabine Hydrochloride
Entry term(s) (R)-(4,4-bis(3-Methyl-2-thienyl)-3-butenyl)-3-piperidinecarboxylic acid, Hydrochloride
Tiagabine, (S)-isomer - Narrower
Concept UI M0324113
Preferred term Tiagabine, (S)-isomer
NO 328 - Narrower
Concept UI M0164770
Preferred term NO 328
Entry term(s) NO-328



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